Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Tittmann, Kai Prof. Dr."
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Mechanistic and Structural Characterization of Thiamine Diphosphate Dependent Enzyme Transketolases from Human and E.coli
(2018-06-06)Thiamine diphosphate (ThDP) dependent enzymes are essential in the metabolism of biological systems, and many of these enzymes are extensively used in the biosynthetic of valuable compounds. In this regard, a comprehensive ... -
Novel Insights in Structure and Mechanism of Escherichia coli Transketolase
(2018-05-18)Thiamine diphosphate (ThDP) dependent enzymes fulfill a number of indispensable functions in metabolism. Further, they are well-researched work-horses of biotechnology. Thus, deepening of our mechanistic and structural ... -
Deciphering the Catalytic Mechanism of the Zn Enzyme Glutaminyl Cyclase and the Deduction of Transition-State Analog Inhibitors
(2015-07-20)Zn(II)-dependent glutaminyl cyclase (QC) converts N-terminal glutamine or glutamate residues of peptides and proteins. The reaction product is in both cases N-terminal pyroglutamic acid (pyroGlu). In animals the glutaminyl ... -
Conformational Sampling of Enzyme dynamics: Triosephosphate Isomerase
(2012-10-17)Triosephosphate Isomerase is a glycolytic enzyme catalyzing the interconversion of Dihydroxyacetone phosphate to Glyceraldehyde-3-phosphate. TIM is a dimer and each monomer is comprised of 249 amino acids. The active ... -
Structural and Funtional Studies on VitaminB1-Dependent Human and Bacterial Transketolases
(2012-08-24)Transketolases (TKs, EC 2.2.1.1) are ubiquitous enzymes in cellular carbohydrate metabolism that require the cofactor thiamin diphosphate for catalytic activity. TKs are involved in numerous metabolic pathways whereas the ...