Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Zweckstetter, Markus Prof. Dr."
Now showing items 1-9 of 9
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NMR spectroscopy of liquid-liquid phase separation related to transcription
(2024-06-05)The Carboxyl-Terminal Domain (CTD) of the largest subunit RPB1 of RNA Polymerase II (Pol II), is a disordered low-complexity region which is crucial for pre-mRNA transcription and processing. Due to its highly repetitive, ... -
Investigation of the role of prolyl isomerase A in protein misfolding associated with neurodegenerative diseases
(2023-06-26)Misfolded proteins and disrupted homeostasis are key characteristics of neurodegenerative diseases. There is a strong association between intrinsically disordered proteins and pathogenic misfolding in neurodegenerative ... -
Investigation on the molecular factors driving the formation of distinct tau 'strains'
(2022-11-28)Pathological aggregation of the microtubule-binding protein tau into amyloid fibrils is a hallmark of different neurodegenerative diseases collectively termed tauopathies. To date, tau amyloid structures associated with ... -
Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau
(2020-12-17)The microtubule-associated protein tau is involved in several neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), Progressive Supranuclear Palsy (PSP) and others. The aggregation and ... -
Structural characterization of alpha-synuclein aggregates seeded by patient material
(2019-12-12)Neurodegenerative diseases share a common underlying pathologic hallmark, the appearance of insoluble protein aggregates in diverse tissues of the nervous system. For many neurodegenerative diseases a common temporal and ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Dynamics and interactions of the voltage-dependent anion channel 1 studied by NMR spectroscopy
(2012-06-20)The voltage-dependent anion channel (VDAC), the most abundant protein in the outer mitochondrial membrane, acts as a gatekeeper for the entry and exit of mitochondrial metabolites and is involved in mitochondrial apoptosis. ... -
Unraveling the structure of monomeric and fibrilized 441-residue tau with NMR spectroscopy
(2011-09-14)The microtubule-associated, intrinsically disordered protein tau is a key- protein in maintaining the axonal transport in neurons. The association to and the dissociation from microtubules is regulated via a complex ... -
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
(2009-10-16)Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, ...