Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Bayer, Thomas A. Prof. Dr."
Now showing items 1-5 of 5
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Ablation of cell-specific cholesterol synthesis affects cerebral β-amyloidosis
(2023-03-13)Cholesterol, an essential membrane component, among others modifies membrane fluidity and regulates cell signaling. CNS cholesterol metabolism is separated from peripheral cholesterol by specific properties of the ... -
Analysis of protein SUMOylation and its role in Alzheimer's disease using mouse models
(2017-04-26)Post-translational modifications serve as a cellular mechanism for the regulation of the activity, stability and localization of proteins. SUMOylation is a dynamic and reversible post-translational modification, which ... -
Effects of recombinant human erythropoietin in the cuprizone mouse model of de- and remyelination
(2012-06-14)Erythropoietin (EPO) has potent neuroprotective/neuroregenerative properties in various forms of experimental autoimmune encephalomyelitis (EAE), i.e. established rodent models of acute multiple sclerosis (MS), and in ... -
Functional properties of microglia in mouse models of Alzheimer’s disease
(2017-02-13)Microglia, resident macrophages of the CNS, execute various functions: they participate in oligodendrogenesis, neurogenesis, learning and behavior, phagocytose harmful material as well as tissue debris and mount crucial ... -
Prion protein-induced proteome alterations in sporadic Creutzfeldt-Jakob disease and in SH-SY5Y cell culture model
(2011-01-11)Cellular prion protein (PrPC) is a glycosylated membrane glycoprotein mainly expressed in the central nervous system. Some still undefined molecular events can lead to the conversion of ...