Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Behr, Rüdiger Prof. Dr."
Now showing items 1-8 of 8
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Genotype-Phenotype Correlation in Noonan Syndrome – Focus on LZTR1 and its Substrates
(2023-05-30)Noonan syndrome (NS) is a multisystemic disorder that is known as one of the most common monogenetic diseases associated with early-onset congenital heart defects, such as hypertrophic cardiomyopathy (HCM). Infants diagnosed ... -
Ablation of cell-specific cholesterol synthesis affects cerebral β-amyloidosis
(2023-03-13)Cholesterol, an essential membrane component, among others modifies membrane fluidity and regulates cell signaling. CNS cholesterol metabolism is separated from peripheral cholesterol by specific properties of the ... -
Mechanisms of chromosome segregation errors in mammalian oocytes
(2023-02-23)During fertilization, a human embryo needs to inherit precisely one copy of each chromosome from both parents. However, human eggs frequently carry an incorrect number of chromosomes, they are aneuploid. Aneuploidy is the ... -
Mechanisms of homologous chromosome synapsis and recombination in mammalian meiosis
(2022-10-13)Homologous chromosome synapsis and recombination are key events that occur during meiotic prophase and result in the formation of chromatin structures called chiasmata. These chromatin structures physically connect ... -
Anti-apoptotic and neuroprotective erythropoietin/CRLF3-signalling in insects and humans
(2022-06-14)The cytokine receptor like factor 3 (CRLF3) evolved together with the eumetazoan nervous system and is present in all major groups of Animalia. Based on sequence similarities, CRLF3 was assigned to the family of class 1 ... -
Mammalian spermiogenesis and the formation of the sperm head to tail coupling apparatus
(2021-08-24)The head-tail coupling apparatus (HTCA), also known as connecting piece, provides the physical linkage between the sperm head and its tail. The HTCA morphogenesis initiates during spermiogenesis and is assembled at the ... -
Role of chromatin remodelling BAF complex in fate regulation of ventral neural stem cells in the developing telencephalon
(2021-01-14)A role for the multi-subunit BAF (mammalian SWI/SNF) complex in brain development has been postulated as its dysfunction causes several neurological diseases, including intellectual disability, schizophrenia, autism spectrum ... -
Embryonic and foetal germ cell development in the marmoset monkey: comparative in situ and cell culture studies
(2018-11-12)Primordial germ cells (PGCs) are the precursors of sperm and egg cells. They arise early in mammalian embryonic development and have to translocate from their extraembryonic tissue of specification over a significant ...