Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Ficner, Ralf Prof. Dr."
Now showing items 1-20 of 86
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A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments
(2023-03-24)One of the major threats for the global health system is the increasing number of antibiotic resistant bacterial strains. The misuse of antibiotics during the Covid pandemic aggravates these problems. Therefore, the ... -
Structure and function of the membrane protein Opa60 by solid-state NMR
(2021-10-18)Studying the structure of transmembrane (TM) proteins is an important task since many of them are drug targets and are involved in essential cellular functions. However, new techniques are urgently needed, as TM proteins ... -
Investigation of the structure of spliceosomal complexes from the yeast S. cerevisiae
(2021-03-19)Nuclear pre-mRNA splicing is catalysed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. It assembles de novo for each round of splicing on premRNA intron with stepwise binding of five small nuclear ... -
Investigation of the mitochondrial contact site and cristae organizing system and its role in cristae formation
(2020-10-27)Mitochondria are essential organelles in eukaryotic cells that feature a unique doublemembrane architecture. The mitochondrial inner membrane forms numerous invaginations, named cristae, which can adopt different shapes ... -
Structural and biochemical characterization of c-di-AMP synthesizing enzymes
(2020-06-11)One major concern of today’s life is the increase of antimicrobial resistance and the rising num-ber of multi drug resistant bacterial species. There is an urgent need of identifying new antibi-otic drug targets since ... -
The RNA helicase Dbp5/DDX19 regulates the ribosomal entry of eRF1-eRF3 and Dom34-Hbs1 in translation termination and cytoplasmic mRNA quality control
(2020-05-22)Translation is a highly regulated and quality-controlled process ensuring the production of correct polypeptides. Although translation initiation is a major target of regulation, translational control occurs also at the ... -
Metabolic fate of jasmonates
(2019-01-21)Jasmonoyl-isoleucine (JA-Ile) is a phytohormone that orchestrates responses to wounding, feeding insects or necrotrophic pathogens in plants. JA-Ile-metabolism has been studied intensively (Wasternack, 2015) and most of ... -
Mechanistic and Structural Characterization of Thiamine Diphosphate Dependent Enzyme Transketolases from Human and E.coli
(2018-06-06)Thiamine diphosphate (ThDP) dependent enzymes are essential in the metabolism of biological systems, and many of these enzymes are extensively used in the biosynthetic of valuable compounds. In this regard, a comprehensive ... -
Novel Insights in Structure and Mechanism of Escherichia coli Transketolase
(2018-05-18)Thiamine diphosphate (ThDP) dependent enzymes fulfill a number of indispensable functions in metabolism. Further, they are well-researched work-horses of biotechnology. Thus, deepening of our mechanistic and structural ... -
Structure of the Pol II initation complex with TFIIH and core Mediator and mechanistic implications for transcription
(2018-03-13)The transcription of protein coding genes is a key step in the conversion of genomic information into the content of a cell’s proteome. In eukaryotes, this process is performed by the multi-subunit DNA-dependent RNA ... -
Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
(2016-09-06)Aspergillus fumigatus is the most prevalent cause for pulmonary infections in immuno-compromised patients. Virulence factors are often linked to developmental control mechanisms, which are often identified in the closely ... -
Function of Elongation Factor P in Translation
(2016-04-25)The ribosome translates the genetic information encoded in the mRNA into amino acid sequence of a peptide chain. The catalytic site of the ribosome where peptide bonds are made, the peptidyl transferase center, consists ... -
Biochemical studies of the synaptic protein otoferlin
(2015-08-27)The C2 domain containing protein otoferlin is required for a late step in exocytosis from auditory inner hair cells and was hypothesized to act as a synaptic Ca2+ sensor. More roles for otoferlin in hair cell synaptic ... -
Structural and functional studies on GTPases involved in eukaryal translation initiation
(2015-06-05)Translation, the process of mRNA-encoded protein biosynthesis, is one of the fundamental processes that are universally conserved in extant cellular life. In all its major stages, namely initiation, elongation, termination ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ... -
Molecular Dynamics Studies of the Phi29 Connector-DNA complex
(2015-04-10)During replication of the Phi29 bacteriophage, a DNA packaging motor packages the viral DNA into the procapsid against a maximum pressure difference of ~60 atm, which is generated by the already packed DNA. Several models ... -
Strukturelle und funktionale Analyse der acetylierten kleinen GTPase Ran
(2015-03-19)The nucleus is the most prominent feature of every eukaryotic cell. Since the nucleus contains virtually all the genetic information it separates the transcription and translation. This separation requires a bidirectional ... -
GlmY and GlmZ: a hierarchically acting cascade composed of two small RNAs
(2014-09-10)In Escherichia coli and other enterobacteria, the homologous small RNAs (sRNAs) GlmY and GlmZ act in a hierarchical manner to feedback control expression of key enzyme glucosamine-6-phosphate (GlcN6P) synthase GlmS. Enzyme ... -
A method for the genetically encoded incorporation of FRET pairs into proteins
(2014-09-03)Proteins are composed of 20 canonical amino acids whose unique arrangements predefine a protein’s structure and function. Importantly, most proteins are not static conformations but rather very dynamic entities that undergo ...