Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Griesinger, Christian Prof. Dr."
Now showing items 1-9 of 9
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Biophysical characterization and computational modeling of phase separation of immune adapter proteins
(2022-07-07)The processes of B cell activation and development are stimulated by antigen binding to the B cell receptor. Pre-signaling clusters are present in unstimulated, resting B cells and assemble by tripartite phase separation ... -
Structure and function of the membrane protein Opa60 by solid-state NMR
(2021-10-18)Studying the structure of transmembrane (TM) proteins is an important task since many of them are drug targets and are involved in essential cellular functions. However, new techniques are urgently needed, as TM proteins ... -
Effects of anle138b treatment on amyloid-β neurotoxicity
(2020-10-02)Alzheimer’s disease (AD), the leading etiology of dementia and the fifth cause of death worldwide, has been declared a public health priority by the World Health Organization in 2017. AD is incurable and no treatment can ... -
Studying the regulation and development of circadian clock by systems biology approaches
(2020-09-24)System biology approaches, coupled with emerging omics tools, have been widely used and greatly accelerated biological and medical research and discovery. In this thesis, I will focus on applying those tools and technologies ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Structural and Funtional Studies on VitaminB1-Dependent Human and Bacterial Transketolases
(2012-08-24)Transketolases (TKs, EC 2.2.1.1) are ubiquitous enzymes in cellular carbohydrate metabolism that require the cofactor thiamin diphosphate for catalytic activity. TKs are involved in numerous metabolic pathways whereas the ... -
Dynamics and interactions of the voltage-dependent anion channel 1 studied by NMR spectroscopy
(2012-06-20)The voltage-dependent anion channel (VDAC), the most abundant protein in the outer mitochondrial membrane, acts as a gatekeeper for the entry and exit of mitochondrial metabolites and is involved in mitochondrial apoptosis. ... -
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
(2009-10-16)Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, ... -
Structural Analysis of a Transactivation Domain Cofactor Complex
(2005-07-29)Signal Transducers and Activators of Transcription (STAT) proteins were discovered as targets for interferon activation. These proteins are dormant in the cytoplasm until they are activated ...