Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Krebber, Heike Prof. Dr."
Now showing items 1-20 of 24
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Regulation of the telomerase
(2025-12-16)Transcription is essential to transfer genetic information and to allow cell viability. Cells must control the resulting traffic of RNA polymerases (RNAP) by holding transcription into gene boundaries and prevent conflicts ... -
Investigations towards a link of morphodynamics and transcriptional pattern in embryonic tissues during morphogenesis
(2025-09-16)The acquisition and loss of epithelial characteristics—such as apico-basal polarity, cell–cell adhesion, and barrier integrity—are essential processes during development, regeneration, and disease. While epithelial–mesenchymal ... -
Analysis of small nucleolar (sno)RNA shuttling in Saccharomyces cerevisiae
(2025-08-07)Small nucleolar (sno)RNAs are a group of non-coding RNAs and can be classified into box C/D snoRNA and box H/ACA snoRNA based on their conserved sequences. They are further associated with snoRNA core proteins to form ... -
Spliceosomal assembly requires a cytoplasmic quality control checkpoint that detects proper U4 and U6 binding in Saccharomyces cerevisiae
(2025-07-30)The precise and well-ordered interactions between nuclear precursor messenger RNAs (pre-mRNA) and the small nuclear RNAs (snRNA), U1, U2, U4, U5, and U6, are essential for intron removal from pre-mRNAs as well as for ... -
Investigation of cytoplasmic long noncoding RNA in Saccharomyces cerevisiae
(2025-06-12)Research on lncRNAs has increased in the past, but little is known about their function. Recently, discoveries have given us insight into sense- and asRNA regulation in yeast. dsRNA is formed in the nucleus and shuttles ... -
A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
Characterization of Npl3 as a 5'- and 3'- quality control factor
(2023-09-11)Maturation of RNA polymerase II transcripts consists of 5’-capping, splicing, cleavage and 3’-polyadenylation. These processes can generate faulty transcripts that have to be retained in the nucleus to be degraded. An mRNA ... -
AntisenseRNA mediated gene regulation via double stranded RNA formation
(2023-03-01)The flow of genetic information in eukaryotic cells is established through transcription from the nuclear DNA into messenger (m)RNA, which travels into the cytoplasm for translation into proteins, the functional units of ... -
Role of N-glycosylation for the function of E-cadherin in tissue morphogenesis
(2022-12-14)E-cadherin is central to the formation, stabilization, and maturation of adherens junctions, which serve to physically link epithelial cells and transmit mechanical pulling forces from the outside to the actomyosin cortex ... -
Characterization of proneural bHLH transcription factor target genes in X. laevis
(2022-09-23)Zc3h12c is a member of the Zc3h12 endoribonuclease family (also known as MCPIP/Regnase), which contains four members (Zc3h12a-c). This family of proteins is characterized by the presence of a single centrally located ... -
Nucleo-cytoplasmic shuttling of snoRNAs in Saccharomyces cerevisiae
(2022-07-19)Small nucleolar RNAs (snoRNAs) are a group of small non-coding RNAs involved in the post-transcriptional modification of RNAs, such as rRNA and tRNA. The importance of their role is evidenced by the rRNA regions subject ... -
Yeast cleavage factor Hrp1 is a novel guard protein that surveils pre-mRNA 3’ processing
(2022-05-10)Hrp1 is a component of the cleavage and polyadenylation complex (CPF-CF) for pre-mRNA cleavage and polyadenylation in S. cerevisiae. It specifically binds to a relatively conserved UA-rich domain called the efficiency-element ... -
Biochemical Analysis of Slam – a polarity protein during early Drosophila embryogenesis
(2021-09-23)Slow as molasses (slam) is a gene essential for embryonic development of Drosophila. Slam is necessary for the formation and ingression of the plasma membrane and its polarisation, i.e. the formation of the basal cortical ... -
The RNA helicase Dbp5/DDX19 regulates the ribosomal entry of eRF1-eRF3 and Dom34-Hbs1 in translation termination and cytoplasmic mRNA quality control
(2020-05-22)Translation is a highly regulated and quality-controlled process ensuring the production of correct polypeptides. Although translation initiation is a major target of regulation, translational control occurs also at the ... -
Quantitative Mass Spectrometric Analysis of RNA-Protein Cross-Links
(2019-11-08)In recent times much emphasis has been laid on revealing the composition and regulation of various RNP complexes. The structural studies of the RNP complexes provide a valuable insight into the binding modes and functional ... -
Symbiotic adaptation of prokaryotic microorganisms in extreme deep-sea environments
(2019-04-10)Extreme deep-sea environments are widespread and intensively studied in the last decades. They are of special interest since living organisms in those habitats happen to live at the expenses of the fluids emitted from the ... -
Analysis of the Asc1p/RACK1 microenvironment in Saccharomyces cerevisiae using proximity-dependent Biotin Identification (BioID) and high-resolution mass spectrometry
(2017-10-11)The conserved ribosome-associated Asc1 protein of Saccharomyces cerevisiae forms a seven bladed β-propeller and binds to the head region of the 40S ribosomal subunit in close proximity to the mRNA exit tunnel. Asc1p is ... -
Structural characterization of autophagy related protein complexes
(2017-06-08)Autophagy is a conserved and highly regulated process in eukaryotic cells that plays an important role in maintaining cellular homeostasis. During macroautophagy a double membrane grows de novo that encloses cytoplasmic ... -
Ribosomal Asc1p/RACK1 in the phosphorylation signaling network of Saccharomyces cerevisiae
(2017-02-10)The WD40 scaffold protein Asc1 of Saccharomyces cerevisiae solely consists of a seven-bladed β propeller. The protein is highly conserved among eukaryotes and known as RACK1 in metazoans and plants. Asc1p/RACK1 localizes ...