Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Moser, Tobias Prof. Dr."
Now showing items 1-12 of 12
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Biochemical studies of the synaptic protein otoferlin
(2015-08-27)The C2 domain containing protein otoferlin is required for a late step in exocytosis from auditory inner hair cells and was hypothesized to act as a synaptic Ca2+ sensor. More roles for otoferlin in hair cell synaptic ... -
Cocaine-inducible circuitry reorganization as a basis for addiction-related memory traces
(2013-01-16)Drug addiction has been conceptualized as an extreme, pathological form of memory. One potential mechanism underlying addiction-related memories is drug-induced plastic changes at glutamatergic synapses within the brain ... -
Dynamic expression of Mover in rodent endbulbs of Held
(2016-05-12)The central auditory pathway contains highly specialized giant presynaptic nerve terminals specialized to preserve temporal information carried by acoustic signals (Oertel et al., 1999). One of them, the endbulbs of Held, ... -
Exploring the Function of a Novel Chronic Pain Player
(2019-06-28)As currently available chronic pain medication is associated with undesirable side effects and suboptimal efficacy, the improvement of treatment options is a major task in the pain research community. The basis for the ... -
Functional organisation of the central complex of the grasshopper <i>Chorthippus biguttulus</i> in relation to sound production
(2008-05-27)The central complex is a major control neuropile for the situation specific selection of sound pattern of grasshoppers. The current thesis tries to investigate the role of different neurotransmitter systems in this brain ... -
Mechanisms of color processing in the retina
(2018-11-27)In the sensory system, many neurons are specified to detect different environmental signals and transfer the signals to downstream neurons. These downstream neurons integrate the detected signals and generate an output ... -
Molecular and structural investigation of assembly, maturation and heterogeneity of inner hair cell ribbon synapses
(2019-10-07)Age-related hearing and balance impairments represent the most common sensory deficits in humans. Both senses rely on hair cell ribbon synapses, which are highly specialized to sustain continuous release of neurotransmitter ... -
Regulation of mechanical feedback amplification in the Drosophila ear
(2022-06-09)Ears achieve their exquisite sensitivity using positive mechanical feedback (Ashmore et al., 2010). Like pushing a swing augments its swing, sound-induced vibrations are enhanced by motile responses of auditory receptor ... -
Resolving the Ultrastructural Organization of Synaptic Vesicle Pools at Hippocampal Mossy Fiber and Schaffer Collateral Synapses
(2021-02-18)The synapse is the functional unit of chemical communication between neurons in the brain. In order to relay information with spatiotemporal precision, the presynaptic compartment utilizes a specialized molecular machinery ... -
The presynaptic protein Mover buffers synaptic plasticity at the hippocampal mossy fiber synapse
(2018-03-12)The increase in the complexity of brains in evolution is accompanied by a surprisingly small number of new synaptic proteins, in particular when considering the remarkably wider range of behavioral responses a primate shows ... -
The role of the presynaptic scaffold protein Bassoon in synaptic transmission at the mouse endbulb of Held synapse
(2013-06-20)Endbulbs of Held are large calyceal presynaptic terminals of auditory nerve fibers driving bushy cells in the AVCN. These synapses transmit precisely timed auditory signals up to high frequencies that provide the basis for ... -
The timing of the final assembly of the SNARE complex in exocytosis
(2010-01-05)Transfer of information between individual neurons via exocytosis is mediated by fusion of secretory vesicles with the plasma membrane and requires assembly of the SNARE proteins Syntaxin-1, SNAP-25 and Synaptobrevin 2 ...