Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 1-17 of 17
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Long-term Replacement of Endogenous Microglia in Mice
(2024-12-19)Microglia are the resident immune cells of the central nervous system (CNS). They play pivotal roles in the development and homeostasis of the CNS and have been implicated in neurodegenerative disorders, such as Alzheimer´s ... -
Protein Signatures of Incision Injury in Humans and Mice - a Translational Study
(2024-05-08)Acute pain is the physiological reaction of a body to noxious external stimuli such as surgical interventions. Depending on the intensity and persistence of pain, tissue recovery may be hampered leading to post-operative ... -
Investigation of the role of prolyl isomerase A in protein misfolding associated with neurodegenerative diseases
(2023-06-26)Misfolded proteins and disrupted homeostasis are key characteristics of neurodegenerative diseases. There is a strong association between intrinsically disordered proteins and pathogenic misfolding in neurodegenerative ... -
The role of RNA in synapse physiology and neurodegeneration in models of Parkinson’s disease
(2022-06-14)Synaptic dysfunction is an early alteration in multiple neurodegenerative disorders. Parkinson’s disease (PD) is characterised by the accumulation of α-synuclein (αsyn) in pathological inclusions known as Lewy bodies ... -
Anti-apoptotic and neuroprotective erythropoietin/CRLF3-signalling in insects and humans
(2022-06-14)The cytokine receptor like factor 3 (CRLF3) evolved together with the eumetazoan nervous system and is present in all major groups of Animalia. Based on sequence similarities, CRLF3 was assigned to the family of class 1 ... -
Proteomic analysis of synaptic dysfunction in the hippocampus of late-stage Parkinson´s Disease
(2022-04-01)The present study focussed on assessing changes in the hippocampus as a result of late-stage Parkinson´s disease. Human post-mortem hippocampal samples were used to address these changes, quantifying significant alterations ... -
Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10
(2021-09-23)This work focuses on elucidating the molecular mechanisms that control the cortical development. Identification of genes and factors that direct the development of the cerebral cortex will both tell us about their ... -
Loss of Setd1b methyltransferase in the murine forebrain as a novel model for human intellectual disability
(2020-12-22)Methylation of histone 3 lysine 4 (H3K4me3) is an epigenetic mark for active transcription, which is mediated in mammals by six enzymes of the SET1/MLL family of histone methyltransferases (KMTs). All of them have been ... -
Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau
(2020-12-17)The microtubule-associated protein tau is involved in several neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), Progressive Supranuclear Palsy (PSP) and others. The aggregation and ... -
Vimentin protects differentiating stem cells from stress
(2020-12-10)Vimentin is the first cytoplasmic intermediate filament to be expressed in mammalian cells during early differentiation, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in ... -
Translocator protein 18 ligand Emapunil protects against neurodegeneration in the MPTP mouse model of Parkinsonism
(2020-06-19)Parkinson’s disease (PD) is the second most common neurodegenerative disorder in old age. The presence of akinesia, rigidity and rest tremor caused by dopaminergic neuronal loss in the substantia nigra are the major clinical ... -
Neurodegeneration induced by ß-synuclein in the context of the neurotransmitter dopamine
(2019-05-27)Objective: α-synuclein and degeneration of dopaminergic neurons have been closely associated to Parkinson´s disease. The interaction of α-synuclein with the neurotransmitter dopamine has been connected to neurodegeneration, ... -
From Chromatin Readers To Neuronal Networks: Finding New Treatments For Alzheimer´s Disease A Transcriptomics Approach
(2018-12-18)Alzheimer’s disease (AD) is the most common dementia-associated neurodegenerative disorder. It has detrimental social and economic impact not only on patients, but also their family and society as a whole. Current estimations ... -
Analysis of the mechanisms of interaction of alpha-synuclein and membranes in cellular models of Parkinson´s Disease
(2018-12-04)Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions known as Lewy bodies. The physiological function ... -
C-terminal tyrosine residue modifications modulate α-synuclein toxicity in yeast as unicellular model for Parkinson´s disease
(2016-12-07)The presence of protein inclusions called Lewy bodies (LBs) that are mainly composed of misfolded and accumulated α-synuclein (αSyn) represents a hallmark of Parkinson´s disease (PD). Oligomeric αSyn species are thought ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Alzheimer-like pathology in murine transgenic models: disease modification by environmental and genetic interventions
(2016-06-01)As no successful therapeutic approach to treat Alzheimer’s disease (AD) has been developed to date, preventative strategies and non-pharmacological interventions increasingly become a major research focus. In recent years, ...