Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Rizzoli, Silvio Prof. Dr."
Now showing items 1-9 of 9
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Is increased Na+ influx a cause of mitochondrial redox stress, cardiomyopathy, and a therapeutic target?
(2023-11-09)Maintaining balanced Na+ levels is critical for normal functioning of cardiomyocytes, including contractions, excitation-contraction coupling (ECC), and metabolism. The NaV1.5-F1759A (human) mutation, which increases ... -
Proteomic analysis of synaptic dysfunction in the hippocampus of late-stage Parkinson´s Disease
(2022-04-01)The present study focussed on assessing changes in the hippocampus as a result of late-stage Parkinson´s disease. Human post-mortem hippocampal samples were used to address these changes, quantifying significant alterations ... -
Insights into the regulation of RNA helicases by protein cofactors
(2019-02-12)RNA helicases comprise a large family of ubiquitously expressed enzymes that remodel RNA structures and RNA-protein complexes in an NTP-dependent manner. These proteins are essential regulators of every RNA-related process, ... -
Genetic and Pharmacological Modulation of Alpha-Synuclein Aggregation
(2017-07-18)Several neurodegenerative disorders, such as Parkinson’s disease (PD), are characterized by the deposition of misfolded and aggregated forms of a particular protein in different areas of the brain. Understanding the molecular ... -
Amyloid-beta driven changes in transcriptome plasticity: From OMICS to Therapy
(2016-04-06)Alzheimer’s disease is characterized by a progressive cognitive decline coinciding with the formation of amyloid plaques and tau fibrils in the human brain. It is the most common form of dementia and the number of people ... -
Extracellular vesicle release of α-Synuclein is mediated by SUMOylation
(2015-11-13)We hypothesized that cells release and transfer α-Syn associated with EVs, followed by highly efficient internalization and induction of α-Syn aggregation in previously healthy neurons. EVs of 40-100 nm diameter can either ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Investigation of myelin membrane adhesion and compaction in the central nervous system
(2013-02-13)Myelin is a multi-layered membrane which enwraps the axons in peripheral (PNS) and central nervous system (CNS). The formation and assembly of this structure is a multi-step process that is regulated by a variety of ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ...