Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Stark, Holger Prof. Dr."
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Function of Elongation Factor P in Translation
(2016-04-25)The ribosome translates the genetic information encoded in the mRNA into amino acid sequence of a peptide chain. The catalytic site of the ribosome where peptide bonds are made, the peptidyl transferase center, consists ... -
Identification and characterization of small molecule inhibitors of pre-mRNA splicing that block spliceosome assembly at novel stages
(2016-02-19)The spliceosome is a highly dynamic, megadalton ribonucleoprotein (RNP) molecular machine that catalyses the important step of the post-transcriptional processing of eukaryotic precursor messenger RNA (pre-mRNA), called ... -
Investigation of the structure of spliceosomal complexes from the yeast S. cerevisiae
(2021-03-19)Nuclear pre-mRNA splicing is catalysed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. It assembles de novo for each round of splicing on premRNA intron with stepwise binding of five small nuclear ... -
Manipulating the Conformational Landscape of Large Macromolecular Complexes
(2022-04-08)The de novo synthesis of fatty acids is one of the most central metabolic pathways in all forms of life. Among all known organisms, fatty acids are highly essential. Besides their role as energy resource, they are also ... -
Molecular Dynamics Studies of the Phi29 Connector-DNA complex
(2015-04-10)During replication of the Phi29 bacteriophage, a DNA packaging motor packages the viral DNA into the procapsid against a maximum pressure difference of ~60 atm, which is generated by the already packed DNA. Several models ... -
Structural and functional characterization of proteins involved in the biogenesis of spliceosomal U snRNPs
(2009-09-11)One major hallmark of eucaryotic organisms is the subdivision of their cells into different, membrane enclosed compartments. In their central compartment, the nucleus, eucaryotes store their ... -
Structural characterization of human spliceosome activation by cryo-EM
(2022-01-27)Eukaryotic genes are transcribed as precursor mRNA (pre-mRNA), in which coding regions (exons) are interrupted by non-coding regions (introns). Introns are excised and exons are ligated together in a two-step process ... -
Structural characterization of the minimal human RISC-loading complex
(2014-03-07)Gene expression is the prerequisite for protein biosynthesis in all cells. Rapid and fine-tuned control of gene expression in response to environmental changes is of great importance. A major gene regulation mechanism in ... -
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome and implications for chromatin remodelling
(2020-07-15)Eukaryotic cells condense their DNA into chromatin, which hampers the accessibility of genetic information. Nucleosomes are the smallest building blocks of chromatin and are comprised of an octameric core of histone proteins, ... -
Structure of the Pol II initation complex with TFIIH and core Mediator and mechanistic implications for transcription
(2018-03-13)The transcription of protein coding genes is a key step in the conversion of genomic information into the content of a cell’s proteome. In eukaryotes, this process is performed by the multi-subunit DNA-dependent RNA ...