Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Urlaub, Henning Prof. Dr."
Now showing items 1-20 of 20
-
Investigation of TOMM20 Interactome in Relation to Protein Quality Control and Translocation
(2024-11-11)The human mitochondria are home to a vast repertoire of approximately 1,500 proteins, most of which are synthesized within the cytosol and post-translationally translocated into the mitochondria. Amidst the intricate ... -
Multi-omics studies of RNA polymerase II transcription regulation by cyclin-dependent kinases
(2024-10-30)Phosphorylation of the C-terminal repeat domain (CTD) of RNA polymerase II (Pol II) plays a central role in the regulation of gene transcription in eukaryotes. In yeast and mammals, the CTD is highly conserved and consists ... -
Structural and functional characterization of TIM22 complex in the inner mitochondrial membarne
(2024-08-16)Mitochondria have gained significant attention in disease models due to their crucial role in cellular energy production and metabolic activity. Understanding how mitochondria maintain their function and interact with other ... -
Protein Signatures of Incision Injury in Humans and Mice - a Translational Study
(2024-05-08)Acute pain is the physiological reaction of a body to noxious external stimuli such as surgical interventions. Depending on the intensity and persistence of pain, tissue recovery may be hampered leading to post-operative ... -
Understanding the role of the transcription factor MGA in primordial germ cell differentiation
(2023-06-20)One of the most crucial cell lineage decisions in mammalian embryos is the differentiation of a few pluripotent epiblast cells into primordial germ cells (PGCs). PGCs are unique for their ability to mature into either sperm ... -
Investigation on the molecular factors driving the formation of distinct tau 'strains'
(2022-11-28)Pathological aggregation of the microtubule-binding protein tau into amyloid fibrils is a hallmark of different neurodegenerative diseases collectively termed tauopathies. To date, tau amyloid structures associated with ... -
Investigating chemical crosslinking of protein-RNA complexes by mass spectrometry
(2022-08-12)RNA plays a quintessential role in cellular processes such as gene expression, transcription, RNA processing, and translation. Proteins carrying out those diverse functions are inherently flexible to accommodate dynamic ... -
HORMA domain proteins in Autophagy initiation
(2022-08-01)The autophagic pathway is an evolutionarily conserved strategy among eukaryotic cells for maintaining cell homeostasis at the basal level and during stressful conditions. It removes protein aggregates, damaged organelles, ... -
Structural studies of short nucleosome arrays containing linker histone H1
(2022-04-21)The DNA inside the eukaryotic nucleus is bound by octamers of histone proteins to form the nucleosome as the basic repeating unit of chromatin. Along the genome, nucleosomes locally form regularly spaced arrays. The relative ... -
Structural characterization of human spliceosome activation by cryo-EM
(2022-01-27)Eukaryotic genes are transcribed as precursor mRNA (pre-mRNA), in which coding regions (exons) are interrupted by non-coding regions (introns). Introns are excised and exons are ligated together in a two-step process ... -
Investigation of the structure of spliceosomal complexes from the yeast S. cerevisiae
(2021-03-19)Nuclear pre-mRNA splicing is catalysed by the spliceosome, a multi-megadalton ribonucleoprotein (RNP) complex. It assembles de novo for each round of splicing on premRNA intron with stepwise binding of five small nuclear ... -
Elucidation of protein-protein interactions in mitochondria by cross-linking mass spectrometry
(2020-08-04)Saccharomyces cerevisiae can generate energy in form of ATP either by fermenting or by respiring nutrition. This depends on the availability of fermentable or non-fermentable carbon sources. The respective energy metabolism ... -
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome and implications for chromatin remodelling
(2020-07-15)Eukaryotic cells condense their DNA into chromatin, which hampers the accessibility of genetic information. Nucleosomes are the smallest building blocks of chromatin and are comprised of an octameric core of histone proteins, ... -
TIP60 acetylation of BMAL1 links positive and negative arms of the molecular circadian clock
(2019-12-11)Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. The far-reaching influence of the circadian organization is illustrated by the ... -
Elucidation of protein interactions in complex samples by protein-protein cross-linking of synaptosomes
(2019-08-23)Synapses are essential structures for inter-cellular communication in the central nervous system between neuronal cells. They form highly-specialized compartments that convert electrical to chemical signals, i.e. ... -
Functional analysis of STRIPAK complex components in the filamentous ascomycete Sordaria macrospora
(2018-08-09)The striatin-interacting phosphatase and kinase (STRIPAK) complex is conserved in fungi and animals. The STRIPAK in the filamentous ascomycete Sordaria macrospora, was previously found to be essential for hyphal fusion and ... -
Structure of the Pol II initation complex with TFIIH and core Mediator and mechanistic implications for transcription
(2018-03-13)The transcription of protein coding genes is a key step in the conversion of genomic information into the content of a cell’s proteome. In eukaryotes, this process is performed by the multi-subunit DNA-dependent RNA ... -
Global Analysis of Protein Phosphorylation Regulation upon Stimulation of Exocytosis in the Nerve Terminal
(2017-06-14)In chemical synapses, neurons communicate with each other via two mechanisms known as fast and slow synaptic transmission. Fast synaptic transmission happens within milliseconds and is triggered by the arrival of an action ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Characterization of chondrogenic progenitor cells using mass spectrometry and multidimensional separation approaches
(2015-07-03)Modern day mass spectrometry (MS) has evolved into a powerful analytical technique, central to the field of proteomics. Currently, the identification and quantification of proteins from different biological samples can be ...