Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Zweckstetter, Markus Prof. Dr."
Now showing items 1-12 of 12
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NMR spectroscopy of liquid-liquid phase separation related to transcription
(2024-06-05)The Carboxyl-Terminal Domain (CTD) of the largest subunit RPB1 of RNA Polymerase II (Pol II), is a disordered low-complexity region which is crucial for pre-mRNA transcription and processing. Due to its highly repetitive, ... -
Characterization of the molecular interaction between α-synuclein and prion protein
(2024-03-21)The interaction between α-synuclein (aSyn) and prion protein (PrP) has been implicated in the pathogenesis of synucleinopathies. However, the nature of this interaction remains poorly understood. Here, we employed a ... -
Investigation of the role of prolyl isomerase A in protein misfolding associated with neurodegenerative diseases
(2023-06-26)Misfolded proteins and disrupted homeostasis are key characteristics of neurodegenerative diseases. There is a strong association between intrinsically disordered proteins and pathogenic misfolding in neurodegenerative ... -
Investigation on the molecular factors driving the formation of distinct tau 'strains'
(2022-11-28)Pathological aggregation of the microtubule-binding protein tau into amyloid fibrils is a hallmark of different neurodegenerative diseases collectively termed tauopathies. To date, tau amyloid structures associated with ... -
Structure and function of the membrane protein Opa60 by solid-state NMR
(2021-10-18)Studying the structure of transmembrane (TM) proteins is an important task since many of them are drug targets and are involved in essential cellular functions. However, new techniques are urgently needed, as TM proteins ... -
Investigation on the Physiological and Pathological Aspects of the Proline-Rich Region of the Microtubule-Associated Protein Tau
(2020-12-17)The microtubule-associated protein tau is involved in several neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), Progressive Supranuclear Palsy (PSP) and others. The aggregation and ... -
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome and implications for chromatin remodelling
(2020-07-15)Eukaryotic cells condense their DNA into chromatin, which hampers the accessibility of genetic information. Nucleosomes are the smallest building blocks of chromatin and are comprised of an octameric core of histone proteins, ... -
Structural characterization of alpha-synuclein aggregates seeded by patient material
(2019-12-12)Neurodegenerative diseases share a common underlying pathologic hallmark, the appearance of insoluble protein aggregates in diverse tissues of the nervous system. For many neurodegenerative diseases a common temporal and ... -
Analysis of the mechanisms of interaction of alpha-synuclein and membranes in cellular models of Parkinson´s Disease
(2018-12-04)Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions known as Lewy bodies. The physiological function ... -
Computational Studies of Small Molecule Permeation across Membrane Channels
(2018-08-13)Membrane channels are an essential part of any life form. They conduct the selective flux across the cell membrane of many important molecules that would otherwise not permeate. Experimental studies on membrane channels ... -
Genetic and Pharmacological Modulation of Alpha-Synuclein Aggregation
(2017-07-18)Several neurodegenerative disorders, such as Parkinson’s disease (PD), are characterized by the deposition of misfolded and aggregated forms of a particular protein in different areas of the brain. Understanding the molecular ... -
Unraveling the structure of monomeric and fibrilized 441-residue tau with NMR spectroscopy
(2011-09-14)The microtubule-associated, intrinsically disordered protein tau is a key- protein in maintaining the axonal transport in neurons. The association to and the dissociation from microtubules is regulated via a complex ...