Browsing Fakultät für Mathematik und Informatik (inkl. GAUSS) by Referee "Wingender, Edgar Prof. Dr."
Now showing items 1-14 of 14
-
Machine learning and statistical analysis to identify determinants of survival in primary glioblastoma using genome wide expression studies
(2022-07-05)Glioblastoma (GBM) is the most common and highly aggressive brain tumor. GBM poses unique challenges due to high rates of tumor recurrence ( 34%) and resistance to treatment. Despite advances in treatment strategies, the ... -
A Bioinformatics Pipeline for Identifying Dysregulated Pathways in Cancer from Comparative RNA-Seq Transcriptome Analysis
(2022-04-07)Cancer is characterized as a multifactorial disease which undergoes genetic and epige- netic changes during invasive tumor growth. Thus, numerous tumor samples have been profiled using high-throughput sequencing technologies ... -
Vorhersage, Analyse und Bedeutung charakteristischer Transkriptionsfaktor-Bindestellen und deren potentielle Masterkontrollfunktion in der transkriptionellen Genregulation
(2021-10-19)In eukaryotes, transcriptional gene regulation is controlled by a set of transcription factors (TFs) and co-factors. Most TFs bind to specific DNA sequences. These binding sites are called transcription factor binding ... -
Using n-layer graph models for representing and transforming knowledge on biological pathways
(2021-03-16)Currently, the use of prior knowledge on biological pathways in research projects is often a manual process, not well documented and hard to reproduce. The aim of this thesis is the definition and implementation of a ... -
Knowledge Integration and Representation for Biomedical Analysis
(2021-02-25)Information-based health systems aimed at improving clinical decision-making are appealing as they are able to cope with the rising amount of information that clinicians are experiencing and provide a framework for ... -
Constructing Temporal Transcriptional Regulatory Cascades in the Context of Development and Cell Differentiation
(2020-07-14)Cell differentiation is a complex process orchestrated by sets of regulators appearing at precise temporal points, resulting in regulatory cascades that affect the expression of broader sets of genes, ending up in the ... -
Information theoretical approaches for the identification of potentially cooperating transcription factors
(2019-08-08)Transcription factors (TFs) are a special class of proteins that usually bind regulatory DNA regions such as promoters and enhancers in order to control the expression of their target genes. Today, it is well known that ... -
Analysis of expression profile and gene variation via development of methods for Next Generation Sequencing data
(2018-11-27)Since the last ten to twenty years, the cost of sequencing the human genome decreased continuously. Therefore the interest in RNA sequencing (RNA-Seq) rose as it can be used to discover the molecular mechanisms behind ... -
Development and application of ontologies for biological applications
(2016-02-08)In the century of information technology automatic processing of knowledge is evolving to be a crucial challenge. However, it is usually not obvious to extract information from the syntax of texts. Hence, ontologies are ... -
Application of A Novel Triclustering Method in Analyzing Three Dimensional Transcriptomics Data
(2015-06-19)Due to the advancement of microarray technology over the last decade, it is feasible to monitor the gene expression dynamics not only over a set of replicates but also either a set of time points or doses of chemical ... -
Detektion und Analyse synergistischer Einflüsse multipler Stimuli auf zelluläre Signaltransduktionsnetzwerke in Säugetieren
(2013-11-21)Simultaneously working signals affect the behavior of organisms at systems level. Different signals have to be integrated and evaluated simultaneously by the cell. Synergistic interactions are one possibility how a cell ... -
Modellierung regulatorischer Netzwerke von Säugetieren und Einsatz von Methoden zur strukturellen Analyse und Identifikation von Kernkomponenten
(2011-06-21)Modeling and analysis of intracellular circuits with graph theoretical approaches has significantly improved the understanding of how regulatory systems are organized. However, only scarce ... -
PAC-Lernen zur Insolvenzvorhersage und Hotspot-Identifikation
(2008-07-22)Methods of machine learning are a very powerful tool in bioinformatics. Due to their versatility they also proof useful in different fields of application. In case of supervised learning, ... -
Evaluierung des phylogenetischen Footprintings und dessen Anwendung zur verbesserten Vorhersage von Transkriptionsfaktor-Bindestellen
(2006-10-27)The human genome contains between 20000 and 25000 genes, which code for proteins, and RNA genes of different function, but approximately 95% of the human genome are presumably not transcribed. ...