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dc.contributor.advisor Trendelenburg, George Prof. Dr.
dc.contributor.author Krey, Lea Farina Magdalena
dc.date.accessioned 2019-07-22T09:57:19Z
dc.date.available 2019-08-14T22:50:03Z
dc.date.issued 2019-07-22
dc.identifier.uri http://hdl.handle.net/21.11130/00-1735-0000-0003-C170-4
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Untersuchungen zur Rolle des Silent information regulator 2 (Sirt2) im experimentellen Schlaganfall in Mäusen de
dc.type doctoralThesis de
dc.title.translated Investigations about silent information regulator 2 (SIRT2) in experimental stroke in mice de
dc.contributor.referee Trendelenburg, George Prof. Dr.
dc.date.examination 2019-08-07
dc.description.abstracteng Sirtuin-2 (Sirt2) is a member of the NAD+-dependent protein deacetylase family. Various members of the sirtuin class have been found to be involved in processes related to longevity, regulation of inflammation, and neuroprotection. Induction of Sirt2-mRNA was found in the whole hemisphere after experimental stroke in a recent screening approach. Moreover, Sirt2 protein is highly expressed in myelin-rich brain regions after stroke. To examine the effects of Sirt2 on ischemic stroke we induced transient focal cerebral ischemia in adult male Sirt2-knockout- and wild-type mice. Two stroke models with different occlusion times were applied: a severe ischemia (45min of middle cerebral artery occlusion; MCAO) and a mild one (15min MCAO), which was used to focus on subcortical infarcts. Neurological deficit was determined at 48h after 45min of MCAO, and up to 7d after induction of 15min of cerebral ischemia. In contrast to recent data on Sirt1, Sirt2-/-mice showed less neurological deficits in both models of experimental stroke with the strongest manifestation after 48h of reperfusion. However, we did not observe a significant difference of stroke volumes or inflammatory cell count between Sirt2-deficient and wild-type mice. Thus, we postulate that Sirt2 mediates myelin-dependent neuronal dysfunction during the early phase after ischemic stroke. de
dc.contributor.coReferee Brück, Wolfgang Prof. Dr.
dc.contributor.thirdReferee Schön, Margarete Prof. Dr.
dc.subject.ger Sirt2 de
dc.subject.ger Schlaganfall de
dc.subject.eng Sirt2 de
dc.subject.eng Stroke de
dc.subject.eng MCAO de
dc.identifier.urn urn:nbn:de:gbv:7-21.11130/00-1735-0000-0003-C170-4-9
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) de
dc.description.embargoed 2019-08-14
dc.identifier.ppn 1672306760

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