Veränderte kortikale Plastizität und Konnektivität bei psychisch nicht erkrankten erstgradigen Angehörigen von Patienten mit einer Schizophrenie

Misewitsch, Kristina

dc.contributor.advisor	Wobrock, Thomas Prof. Dr.
dc.contributor.author	Misewitsch, Kristina
dc.date.accessioned	2019-07-31T10:22:59Z
dc.date.available	2019-07-31T10:22:59Z
dc.date.issued	2019-07-31
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0003-C182-F
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7584
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Veränderte kortikale Plastizität und Konnektivität bei psychisch nicht erkrankten erstgradigen Angehörigen von Patienten mit einer Schizophrenie	de
dc.type	doctoralThesis	de
dc.title.translated	Altered cortical plasticity and connectivity in unaffected first-degree relatives of patients with schizophrenia	de
dc.contributor.referee	Antal, Andrea Prof. Dr.
dc.date.examination	2019-08-08
dc.description.abstracteng	Content: Impaired cortical plasticity and brain dysconnectivity are discussed to be essential pathomechanisms of schizophrenia. NMDA receptors, glutamate and intracellular calcium concentration play a key role in this regard. The aim of the present study was to investigate differences in motor-cortical plasticity and interhemisphreic connectivity in unaffected first-degree relatives compared to schizophrenia patients and healthy subjects using cathodal transcranial direct current stimulation (tDCS) and TMS. Methods: To induce LTD-like plasticity the left primary motor cortex was stimulated by cathodal tDCS. Cortical excitability was determined by transcranial magnet stimulation (MEP amplitudes) before and after cathodal stimulation over the motor cortices of both hemispheres. Furthermore, the cortical silent periot and resting motor thresholds were measured before and after tDCS Results: Relatives and patients showed impaired motorcortical LTD-like plasticity responses over the stimulated hemisphere compared to the healthy control group. On the non-stimulated hemisphere, patients with schizophrenia exhibited reduced LTD-like plasticity, while in first-degree relatives reversed LTD-like plasticity was observed. Conclusions: The findings provide experimental evidence for the influence of genetic risk on LTD-like cortical plasticity and the associated interhemispheric connectivity following cathodal tDCS. The familial predisposition changes and inverts the cortical plasticity of unaffected relatives. An imbalance of glutamatergic and dopaminergic transmission can be discussed in addition to deficits of GABAergic neurotransmission possible pathomechanisms.	de
dc.contributor.coReferee	Meyer, Thomas Prof. Dr.
dc.subject.ger	Schizophrenie	de
dc.subject.ger	Plastizität	de
dc.subject.ger	TMS	de
dc.subject.ger	tDCS	de
dc.subject.ger	Gleichstromstimulation	de
dc.subject.ger	Konnektivität	de
dc.subject.eng	schizophrenia	de
dc.subject.eng	plasticity	de
dc.subject.eng	TMS	de
dc.subject.eng	connectivity	de
dc.subject.eng	tDCS	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0003-C182-F-7
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Psychiatrie (PPN619876344)	de
dc.identifier.ppn	1672307120

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