Algorithms for Crystal Structure Determination in Macromolecular Crystallography

Lübben, Anna

dc.contributor.advisor	Sheldrick, George M. Prof. Dr.
dc.contributor.author	Lübben, Anna
dc.date.accessioned	2019-11-25T10:57:24Z
dc.date.available	2019-11-25T10:57:24Z
dc.date.issued	2019-11-25
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-12B9-6
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7681
dc.language.iso	eng	de
dc.publisher	Niedersächsische Staats- und Universitätsbibliothek Göttingen	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	540	de
dc.title	Algorithms for Crystal Structure Determination in Macromolecular Crystallography	de
dc.type	doctoralThesis	de
dc.contributor.referee	Sheldrick, George M. Prof. Dr.
dc.date.examination	2019-06-21
dc.description.abstracteng	X-ray crystallography has been the leading technique for structure determination since the discovery of the diffraction of X-rays by crystals by Max von Laue. In this thesis the crystal structure of human ceroid lipofuscinosis neuronal protein 5 (cln5) is described for the first time. The structure solution is the basis to further the understanding of neuronal ceroid lipofuscinosis 5 (NCL 5) disease, since now structural homologues can be described, and it becomes possible to deduce a function for the protein cln5. The program PDB2INS was developed as a bridge for the refinement of macromolecular crystallography data with the program SHELXL. As part of this thesis the development of the program, its functions, and capabilities are described. In 1961, A. Rich, D. Davies, F. Crick and J. Watson proposed a parallel double helix ribonucleic acid (RNA) structure for poly(rA). Here high-resolution data of poly(rA) is presented and analyzed in the context of multi crystal averaging. The analysis is part of the effort to implement this function into SHELXC by G. M. Sheldrick.	de
dc.contributor.coReferee	Tittmann, Kai Prof. Dr.
dc.contributor.thirdReferee	Steinfeld, Robert Prof. Dr. Dr.
dc.subject.eng	Crystallography	de
dc.subject.eng	Structure determination	de
dc.subject.eng	PDB2INS	de
dc.subject.eng	CLN5	de
dc.subject.eng	neuronal ceroid lipofuscinosis	de
dc.subject.eng	poly(rA)	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-12B9-6-8
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.identifier.ppn	168346169X

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Beschreibung:: Doctoral Thesis by Anna V. Lübben

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Fakultät für Chemie (inkl. GAUSS) [702]

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