Prognostische Bedeutung seltener Einzelchromosomenanomalien bei myelodysplastischen Syndromen

Prognostic impact of rare single chromosomatic anomalities at myelodysplastic syndroms

by Bärbel Christa Elfriede Rothmann
Doctoral thesis
Date of Examination:2020-01-15
Date of issue:2020-01-03
Advisor:PD Dr. Julie Schanz
Referee:Prof. Dr. Heidi Eva Hahn
Referee:Prof. Dr. Margarete Schön
Persistent Address: http://dx.doi.org/10.53846/goediss-7792

 

 

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Abstract

English

Cytogenetic in myelodysplastic syndromes offer a valid prognostic factor for OS and AML free survival in the IPSS-R. For roughly 90% of cytogenetic abnormalities the prognostic impact is already known. This analysis therefore deals with some of these rare single abnormalities within the remaining 10%. More than 7000 cases where screened. Core results refer to the del(13q) and balanced translocations with a significantly better survival rate and to abnormalities at chromosomes 20 (without del (20q)) and patients with monosomie 9 which have a significantly shorter overall survival rate. For monosomie 9 patients and such with chromosome 20 abnormalities this applies for the AML free survival as well.
Keywords: myelodysplastic syndrom; rare single chromosomic abnormalities
 
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