Einfluss der Nahrungsaufnahme auf die Lebersteifigkeit, gemessen mit 2D-Scherwellen-Elastographie (Gerät: LOGIQ E9) bei freiwilligen Probanden

Porsche, Melissa

dc.contributor.advisor	Neeße, Albrecht PD Dr.
dc.contributor.author	Porsche, Melissa
dc.date.accessioned	2020-02-19T09:07:06Z
dc.date.available	2020-02-26T23:50:03Z
dc.date.issued	2020-02-19
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-1326-B
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7821
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7821
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Einfluss der Nahrungsaufnahme auf die Lebersteifigkeit, gemessen mit 2D-Scherwellen-Elastographie (Gerät: LOGIQ E9) bei freiwilligen Probanden	de
dc.type	doctoralThesis	de
dc.title.translated	Impact of Food Intake on Liver Stiffness Determined by 2D Shear Wave Elastography (LOGIQ E9): Prospective Interventional Study in 100 Healthy Patients	de
dc.contributor.referee	Neeße, Albrecht PD Dr.
dc.date.examination	2020-02-19
dc.description.abstracteng	The aim was to evaluate the influence of food intake on liver stiffness measurement (LSM), performed with 2-D shear wave elastography (Logiq E9, GE Medical Systems, Wauwatosa, WI, USA). One hundred healthy volunteers were prospectively enrolled. Mean age was 25.8 (19-55) y, and mean body mass index was 22.43 (17.3-30.8) kg/m². Patients fasted for at least 3 h and subsequently ingested a liquid meal of 800 kcal. Liver stiffness and portal vein velocity were measured before and after food intake. Food intake resulted in significantly higher LSM values compared with baseline LSM (5.74 ± 0.94 kPa vs. 4.80 ± 0.94 kPa, p < 0.001). On multiple linear regression analysis, body mass index was significantly positively correlated with the LSM increase after food intake (p = 0.01). No correlation between the increase in LSM and the increase in post-prandial portal vein velocity was observed (r = 0.09). In summary, food intake has a significant influence on LSM. There is an 11% risk of misclassifying non-fasting, healthy patients as having significant fibrosis.	de
dc.contributor.coReferee	Rosewich, Hendrik PD Dr.
dc.subject.eng	Elastographie	de
dc.subject.eng	Lebersteifigkeit	de
dc.subject.eng	Nahrungsaufnahme	de
dc.subject.eng	2D-Scherwellen-Elastographie	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-1326-B-3
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Gastroenterologie (PPN61987578X)	de
dc.subject.gokfull	Diagnostik {Medizin} (PPN619875739)	de
dc.description.embargoed	2020-02-26
dc.identifier.ppn	169044780X

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