• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Decis State - Dysfunktionen neuronaler Mechanismen der Impulskontrolle bei Suchterkrankung –eine funktionell-kernspintomographische Untersuchung von Patienten mit langjähriger Alkoholabhängigkeit

DECIS-State: Dysfunctional neural mechanisms of impulse control of addiction- A functional neuroimaging study of patients with longstanding alcohol addiction

by Jasmin Said
Doctoral thesis
Date of Examination:2020-05-27
Date of issue:2020-05-26
Advisor:Prof. Dr. Oliver Gruber
Referee:Prof. Dr. Melanie Wilke
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-7993

 

 

Files in this item

Name:Disseration-Jasmin.Said_SUB.pdf
Size:2.45Mb
Format:PDF
ViewOpen

The following license files are associated with this item:


Abstract

English

The mesolimbic dopamine system plays a central role in the development of addiction. Some of its areas enable quick (impulsive) desires for preferred or conditioned stimuli. On the other hand, pre-frontal areas, which are disturbed in addictive patients, suppress impulsive behavior in favor of a long-term goal.

A functional magnetic resonance imaging with a DRD-Paradigm was used to investigate potential dysfunctions of neurofunctional systems of impulse control in patients with longstanding alcohol dependence.

17 patients and 15 controls were included in the clinical prospective study.

As expected, the abstinent alcoholics activated the areas of the mesolimbic dopamine system during presentation of alcoholic stimuli. In the Desire context, however, the patients showed a reduced activation of these areas. Together, these findings point to a higher salience of alcohol-associated stimuli. Moreover, it also took the patients longer to refuse alcoholic stimuli. Finally, in Reason-context the abstinent alcoholics showed a top-down suppression effect to alcoholic stimuli in favor of a long-term goal. We interpret this finding as a successful therapeutic effect after inpatient treatment.

Keywords: Impulse control
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]