| dc.contributor.advisor | Djukic, Marija Prof.Dr. | |
| dc.contributor.author | Onken, Marie Luise | |
| dc.date.accessioned | 2020-09-10T13:24:42Z | |
| dc.date.available | 2020-10-13T22:50:02Z | |
| dc.date.issued | 2020-09-10 | |
| dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-1480-3 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8188 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Vitamin D- Immunmodulator der bakteriellen Meningitis | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Vitamin D- Immunmodulator of the bacterial meningitis | de |
| dc.contributor.referee | Weber, Martin Prof. Dr. | |
| dc.date.examination | 2020-12-31 | |
| dc.description.abstracteng | Meningitis and meningoencephalitis caused by Escherichia coli are associated with high rates of mortality and neurological sequelae. A high prevalence of neurological disorders has been observed in geriatric populations at risk of hypovitaminosis D. Vitamin D has potent effects on human immunity including induction of antimicrobial peptides (AMPs) and suppression of T-cell proliferation, but its influence on microglial cells is unknown. The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing and immune response of murine microglia cultures after stimulation with the Toll-like receptors (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), Polynosine-polycytidylic acid (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9). Upon stimulation with high concentrations of TLR agonists, the release of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 was decreased in vitamin D-deficient compared to vitamin D-sufficient microglial cultures. Phagocytosis of E. coli K1 after stimulation of microglial cells with high concentrations of TLR 3, - 4 and 9 agonists and intracellular killing of E. coli K1 after stimulation with high concentrations of all TLR agonists was lower in vitamin D-deficient microglial than in the respective control cells. Our observations suggest that vitamin D deficiency may impair the resistance of the brain against bacterial infections. | de |
| dc.contributor.coReferee | Oppermann, Martin Prof. Dr. | |
| dc.subject.eng | bacterial meningitis | de |
| dc.subject.eng | vitamin D | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-1480-3-0 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2020-12-31 | |
| dc.identifier.ppn | 1730473407 | |