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Vitamin D- Immunmodulator der bakteriellen Meningitis

dc.contributor.advisorDjukic, Marija Prof.Dr.
dc.contributor.authorOnken, Marie Luise
dc.titleVitamin D- Immunmodulator der bakteriellen Meningitisde
dc.title.translatedVitamin D- Immunmodulator of the bacterial meningitisde
dc.contributor.refereeWeber, Martin Prof. Dr.
dc.description.abstractengMeningitis and meningoencephalitis caused by Escherichia coli are associated with high rates of mortality and neurological sequelae. A high prevalence of neurological disorders has been observed in geriatric populations at risk of hypovitaminosis D. Vitamin D has potent effects on human immunity including induction of antimicrobial peptides (AMPs) and suppression of T-cell proliferation, but its influence on microglial cells is unknown. The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing and immune response of murine microglia cultures after stimulation with the Toll-like receptors (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), Polynosine-polycytidylic acid (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9). Upon stimulation with high concentrations of TLR agonists, the release of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 was decreased in vitamin D-deficient compared to vitamin D-sufficient microglial cultures. Phagocytosis of E. coli K1 after stimulation of microglial cells with high concentrations of TLR 3, - 4 and 9 agonists and intracellular killing of E. coli K1 after stimulation with high concentrations of all TLR agonists was lower in vitamin D-deficient microglial than in the respective control cells. Our observations suggest that vitamin D deficiency may impair the resistance of the brain against bacterial infections.  de
dc.contributor.coRefereeOppermann, Martin Prof. Dr.
dc.subject.engbacterial meningitisde
dc.subject.engvitamin Dde
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de

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