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Late-Stage Peptide Diversification via Transition Metal-Catalyzed C─H Activation

dc.contributor.advisorAckermann, Lutz Prof. Dr.
dc.contributor.authorWang, Wei
dc.date.accessioned2020-10-13T11:46:15Z
dc.date.available2020-10-13T11:46:15Z
dc.date.issued2020-10-13
dc.identifier.urihttp://hdl.handle.net/21.11130/00-1735-0000-0005-14AE-1
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-8217
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-8217
dc.language.isoengde
dc.publisherNiedersächsische Staats- und Universitätsbibliothek Göttingende
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc540de
dc.titleLate-Stage Peptide Diversification via Transition Metal-Catalyzed C─H Activationde
dc.typedoctoralThesisde
dc.contributor.refereeAckermann, Lutz Prof. Dr.
dc.date.examination2020-09-17
dc.description.abstractengThe late-stage modification of peptide is of great value to drug discovery and medicinal chemistry. Metal catalyzed C─H activation has emerged as efficient and step-economic strategy for post-translational peptide engineering. Within this thesis, palladium-catalyzed peptide arylation was achieved via isosteric triazole assistance, which was further applied for direct peptide BODIPY fluorescent labeling and the synthesis of BODIPY labeled cyclobutanes. Additionally, low toxicity 3d metal manganese was employed for peptide glycol-conjugation for the first time, delivering glycopeptides and mimetic of naturally occurring glycol-tryptophan. A direct peptide CꟷN formation was developed for highly regioselective peptide C7 amidation, offering an avenue for further peptide diversifications.de
dc.contributor.coRefereeBreder, Alexander Prof. Dr.
dc.contributor.thirdRefereeTietze, Lutz Prof. Dr.
dc.contributor.thirdRefereeKoszinowski, Konrad Prof. Dr.
dc.contributor.thirdRefereeJohn, Michael Dr.
dc.contributor.thirdRefereeWalker, Johannes Jun.-Prof. Dr.
dc.subject.engC–H Activationde
dc.subject.engLate-Stage Peptidede
dc.subject.engChemical Ligationde
dc.subject.engFluorescent Labelingde
dc.subject.engGlyco-conjugationde
dc.subject.engCꟷN Formationde
dc.subject.engTryptophan C7 Activationde
dc.identifier.urnurn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14AE-1-9
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de
dc.identifier.ppn1735493228


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