Late-Stage Peptide Diversification via Transition Metal-Catalyzed C─H Activation

Wang, Wei

dc.contributor.advisor	Ackermann, Lutz Prof. Dr.
dc.contributor.author	Wang, Wei
dc.date.accessioned	2020-10-13T11:46:15Z
dc.date.available	2020-10-13T11:46:15Z
dc.date.issued	2020-10-13
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-14AE-1
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8217
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8217
dc.language.iso	eng	de
dc.publisher	Niedersächsische Staats- und Universitätsbibliothek Göttingen	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	540	de
dc.title	Late-Stage Peptide Diversification via Transition Metal-Catalyzed C─H Activation	de
dc.type	doctoralThesis	de
dc.contributor.referee	Ackermann, Lutz Prof. Dr.
dc.date.examination	2020-09-17
dc.description.abstracteng	The late-stage modification of peptide is of great value to drug discovery and medicinal chemistry. Metal catalyzed C─H activation has emerged as efficient and step-economic strategy for post-translational peptide engineering. Within this thesis, palladium-catalyzed peptide arylation was achieved via isosteric triazole assistance, which was further applied for direct peptide BODIPY fluorescent labeling and the synthesis of BODIPY labeled cyclobutanes. Additionally, low toxicity 3d metal manganese was employed for peptide glycol-conjugation for the first time, delivering glycopeptides and mimetic of naturally occurring glycol-tryptophan. A direct peptide CꟷN formation was developed for highly regioselective peptide C7 amidation, offering an avenue for further peptide diversifications.	de
dc.contributor.coReferee	Breder, Alexander Prof. Dr.
dc.contributor.thirdReferee	Tietze, Lutz Prof. Dr.
dc.contributor.thirdReferee	Koszinowski, Konrad Prof. Dr.
dc.contributor.thirdReferee	John, Michael Dr.
dc.contributor.thirdReferee	Walker, Johannes C. L. Prof. Dr.
dc.subject.eng	C–H Activation	de
dc.subject.eng	Late-Stage Peptide	de
dc.subject.eng	Chemical Ligation	de
dc.subject.eng	Fluorescent Labeling	de
dc.subject.eng	Glyco-conjugation	de
dc.subject.eng	CꟷN Formation	de
dc.subject.eng	Tryptophan C7 Activation	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14AE-1-9
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.identifier.ppn	1735493228

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