FGFR-Alterationen in primären und oligometastasierten kolorektalen Karzinomen

Fromme, Julia Elisabeth

dc.contributor.advisor	Schildhaus, Hans-Ulrich Prof. Dr.
dc.contributor.author	Fromme, Julia Elisabeth
dc.date.accessioned	2020-11-03T07:27:25Z
dc.date.available	2020-11-24T23:50:02Z
dc.date.issued	2020-11-03
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0005-14D3-6
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8291
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8291
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	FGFR-Alterationen in primären und oligometastasierten kolorektalen Karzinomen	de
dc.type	doctoralThesis	de
dc.title.translated	FGFR alterations in primary and oligometastatic colorectal cancer	de
dc.contributor.referee	Bleckmann, Annalen Prof. Dr.
dc.date.examination	2020-11-17
dc.description.abstracteng	The outcome of metastatic colorectal cancer patients is up to now unsatisfactory and there is a need for effective therapeutic options. Fibroblast growth factor receptor (FGFR) and FGF ligand alterations have been investigated in various solid tumors, the doctoral thesis at hand focusses on FGFR and FGF alterations in colorectal cancer. Primary tumors and liver metastases of colorectal cancer patients have been analyzed for FGFR alterations. In primary tumors as well as in metastases alterations on DNA and RNA level could be detected. The data suggest that in metastases certain FGFR alterations have also a prognostic relevance, thus providing a potential rationale for including these patients into clinical trials with anti-FGFR treatment.	de
dc.subject.ger	Kolorektales Karzinom	de
dc.subject.ger	FGFR	de
dc.subject.eng	colorectal cancer	de
dc.subject.eng	FGFR	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-14D3-6-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674)	de
dc.description.embargoed	2020-11-24
dc.identifier.ppn	1737715805

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Human- und Zahnmedizin [2873]

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