| dc.contributor.advisor | Schliephake, Henning Prof. Dr. Dr. | |
| dc.contributor.author | Baron von Hahn, Nikolaus | |
| dc.date.accessioned | 2021-01-15T09:39:28Z | |
| dc.date.available | 2021-02-02T23:50:02Z | |
| dc.date.issued | 2021-01-15 | |
| dc.identifier.uri | http://hdl.handle.net/21.11130/00-1735-0000-0005-154A-1 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-8397 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Untersuchung der Freisetzungskinetik unterschiedlicher mit rh-BMP-2 beladener Polyelektrolyt-Multilayer-Schichten auf Titanplättchen | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Investigation of the release kinetics of different polyelectrolyte multilayer coatings loaded with rh-BMP-2 on titanium platelets. | de |
| dc.contributor.referee | Miosge, Nicolai Prof. Dr. | |
| dc.date.examination | 2021-01-26 | |
| dc.description.abstracteng | The aim of this in vitro study was to investigate the release kinetics of rh-BMP-2 from polyelectrolyte multilayers on titanium platelets of different modifications. The heparin PEM showed sufficient loading of rh-BMP-2 and comparable release amounts and kinetics as previous studies (Guillot et al. 2013). After adding collagen to the coating to better simulate the ECM, a slightly lower amount of released rh-BMP-2 was shown, but with a release amount of at least 100 ng/72 h over 21 days, which seems necessary to induce efficient bone neosynthesis (Gruber et al. 2009).
The cross-linking of the polyelectrolyte multilayers did not lead to the hoped-for delayed release kinetics. It was found that chemical crosslinking by EDC/NHS reaction led to a comparable release in terms of amount of protein and release pattern as the non-crosslinked coatings, whereas photochemical crosslinking by UV-crosslinking led to a very low, unusable BMP-2 release. | de |
| dc.contributor.coReferee | Oppermann, Martin Prof. Dr. | |
| dc.subject.eng | growth factors | de |
| dc.subject.eng | BMP-2 | de |
| dc.subject.eng | polyelectrolyte multilayers | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-21.11130/00-1735-0000-0005-154A-1-7 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Zahn-, Mund- und Kieferheilkunde - Allgemein- und Gesamtdarstellungen (PPN619876360) | de |
| dc.description.embargoed | 2021-02-02 | |
| dc.identifier.ppn | 1744838100 | |