C–H and C–F Activation by Manganese, Nickel and Ruthenium Catalysis

Müller, Valentin

dc.contributor.advisor	Ackermann, Lutz Prof. Dr.
dc.contributor.author	Müller, Valentin
dc.date.accessioned	2021-04-19T12:10:37Z
dc.date.available	2021-04-29T09:53:52Z
dc.date.issued	2021-04-19
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0008-57F6-1
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8541
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8541
dc.language.iso	eng	de
dc.publisher	Niedersächsische Staats- und Universitätsbibliothek Göttingen	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	540	de
dc.title	C–H and C–F Activation by Manganese, Nickel and Ruthenium Catalysis	de
dc.type	doctoralThesis	de
dc.contributor.referee	Ackermann, Lutz Prof. Dr.
dc.date.examination	2021-03-29
dc.description.abstracteng	The development of novel environment-friendly, step- and atom-economical methodologies is one of the main goals in organic chemistry. In this context, the direct functionalization of inert C–(Het) and C–H bonds has emerged as an environmentally-benign alternative that avoids lengthy syntheses and stoichiometric amounts of waste, and has therefore attracted broad interest with applications also to chemical industries. In this thesis, several methods have been devised in terms of efficiency, diversity and sustainability. In this context, nickel-catalyzed C–F alkylations by a novel bidentate SPO/nickel catalyst and enantioselective aluminum-free alkene hydroarylations via C–H activation by a chiral nickel/JoSPOphos manifold were developed. Furthermore, C−H/C−F functionalizations, via earth-abundant manganese catalysis, set the stage for a variety of step-economical (per)fluoro allylations and alkenylations exclusively resulting in the forming of the (Z)-isomer. Moreover, ruthenium(II)-catalyzed hydrogen isotope exchange (HIE) of various carboxylic acids, as well as active pharmazeutical ingredients (APIs) were developed, yielding deuterium and tritium labeled scaffolds. Finally, a hybrid ruthenium catalyst for meta C−H alkylations in a reusable manner with broad applicability was developed.	de
dc.contributor.coReferee	Das, Shoubhik Prof. Dr.
dc.contributor.thirdReferee	Koszinowski, Konrad Prof. Dr.
dc.contributor.thirdReferee	Stalke, Dietmar Prof. Dr.
dc.contributor.thirdReferee	Walker, Johannes C. L. Prof. Dr.
dc.contributor.thirdReferee	Frauendorf, Holm Dr.
dc.subject.eng	C–H Activation	de
dc.subject.eng	Catalysis	de
dc.subject.eng	Asymmetric catalysis	de
dc.subject.eng	3d transition metals	de
dc.subject.eng	C–F Activation	de
dc.subject.eng	Heterogeneous catalysis	de
dc.subject.eng	Hydrogen Isotope Exchange (HIE)	de
dc.subject.eng	Active Pharmaceutical Ingredient (API)	de
dc.subject.eng	Nickel catalysis	de
dc.subject.eng	Manganese catalysis	de
dc.subject.eng	Ruthenium catalysis	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-57F6-1-2
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.description.embargoed	2021-04-25
dc.identifier.ppn	1755402406

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