Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz

Fricke, Marilis

dc.contributor.advisor	Zerr, Inga Prof. Dr.
dc.contributor.author	Fricke, Marilis
dc.date.accessioned	2021-06-22T07:46:02Z
dc.date.available	2021-07-06T00:50:09Z
dc.date.issued	2021-06-22
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0008-586F-A
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8687
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz	de
dc.type	doctoralThesis	de
dc.title.translated	Effects of cardiovascular risk factors as well as various pre-existing diseases on the course of Alzheimer's dementia	de
dc.contributor.referee	Zerr, Inga Prof. Dr.
dc.date.examination	2021-06-29
dc.description.abstracteng	Alzheimer’s disease is the most common form of dementias. Among patients with Alzheimer’s disease different rates of progression have been observed, not knowing which risk factors could lead to faster cognitive decline. Within this dissertation 90 patients with Alzheimer’s were examined in a study of the University Medical Centre Göttingen. Based on a minimum of two follow up examinations using the MMSE (Mini Mental State Examination), patients were classified into two groups: Alzheimer’s dementia and rapidly progressive Alzheimer’s disease. A multitude of risk factors including cardiovascular risk factors, cancer, surgical intervention and other risk factors were examined retrospectively with regard to their contribution to the classification into one of the groups, and their connection to a faster cognitive decline of the patients. We found evidence, that patients suffering from Alzheimer’s and diabetes mellitus or coronary heart disease showed a significantly slower cognitive decline in this cohort. Possible reasons for this observation could be crossing neurochemical pathways in both Alzheimer’s disease and diabetes mellitus. The effect of antidiabetic or antihypertensive medication could play an important role, too. Prospective studies with more detailed information concerning the risk factors are required to identify reasons leading to this context. Other risk factors showed no impact on cognitive development within the two groups.	de
dc.contributor.coReferee	Unkel, Steffen PD Dr.
dc.subject.ger	Alzheimer-Demenz	de
dc.subject.ger	Risikofaktoren	de
dc.subject.ger	rapid progressive Alzheimer-Demenz	de
dc.subject.ger	Diabetes mellitus	de
dc.subject.eng	Alzheimer's disease	de
dc.subject.eng	risk factors	de
dc.subject.eng	rapidly progressive Alzheimer's disease	de
dc.subject.eng	Diabetes mellitus	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-586F-A-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Neuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255)	de
dc.description.embargoed	2021-07-06
dc.identifier.ppn	1761077589 1761077562

Dateien

Name:Doktorarbeit Marilis Fricke 02.06.2021.pdf

Größe:1.354Mb

Format:PDF

Öffnen

Name:: Doktorarbeit Marilis Fricke ...
Größe:: 1.354Mb
Format:: PDF

Öffnen

Das Dokument erscheint in:

Human- und Zahnmedizin [2880]

Zur Kurzanzeige