Show simple item record

Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz

dc.contributor.advisorZerr, Inga Prof. Dr.
dc.contributor.authorFricke, Marilis
dc.titleAuswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenzde
dc.title.translatedEffects of cardiovascular risk factors as well as various pre-existing diseases on the course of Alzheimer's dementiade
dc.contributor.refereeZerr, Inga Prof. Dr.
dc.description.abstractengAlzheimer’s disease is the most common form of dementias. Among patients with Alzheimer’s disease different rates of progression have been observed, not knowing which risk factors could lead to faster cognitive decline. Within this dissertation 90 patients with Alzheimer’s were examined in a study of the University Medical Centre Göttingen. Based on a minimum of two follow up examinations using the MMSE (Mini Mental State Examination), patients were classified into two groups: Alzheimer’s dementia and rapidly progressive Alzheimer’s disease. A multitude of risk factors including cardiovascular risk factors, cancer, surgical intervention and other risk factors were examined retrospectively with regard to their contribution to the classification into one of the groups, and their connection to a faster cognitive decline of the patients. We found evidence, that patients suffering from Alzheimer’s and diabetes mellitus or coronary heart disease showed a significantly slower cognitive decline in this cohort. Possible reasons for this observation could be crossing neurochemical pathways in both Alzheimer’s disease and diabetes mellitus. The effect of antidiabetic or antihypertensive medication could play an important role, too. Prospective studies with more detailed information concerning the risk factors are required to identify reasons leading to this context. Other risk factors showed no impact on cognitive development within the two
dc.contributor.coRefereeUnkel, Steffen PD Dr.
dc.subject.gerrapid progressive Alzheimer-Demenzde
dc.subject.gerDiabetes mellitusde
dc.subject.engAlzheimer's diseasede
dc.subject.engrisk factorsde
dc.subject.engrapidly progressive Alzheimer's diseasede
dc.subject.engDiabetes mellitusde
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullNeuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255)de
dc.identifier.ppn1761077589 1761077562

Files in this item


This item appears in the following Collection(s)

Show simple item record