Neutrophil Extracellular Traps (NETs) in der Interleukin-23-induzierten psoriasiformen Dermatitis

Manzke, Veit Steffen

dc.contributor.advisor	Schön, Michael P. Prof. Dr.
dc.contributor.author	Manzke, Veit Steffen
dc.date.accessioned	2021-07-14T10:57:36Z
dc.date.available	2021-08-03T00:50:04Z
dc.date.issued	2021-07-14
dc.identifier.uri	http://hdl.handle.net/21.11130/00-1735-0000-0008-58A9-7
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-8732
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Neutrophil Extracellular Traps (NETs) in der Interleukin-23-induzierten psoriasiformen Dermatitis	de
dc.type	doctoralThesis	de
dc.title.translated	Neutrophil Extracellular Traps (NETs) in Interleukin-23-mediated psoriasis-like skin inflammation	de
dc.contributor.referee	Walter, Lutz Prof. Dr.
dc.date.examination	2021-07-27
dc.description.abstracteng	Psoriasis is a chronic recurrent inflammatory disease of the skin and joints, often associated with significant morbidity. In spite of its clinical importance, the pathogenesis of psoriasis is not fully understood. Recently, it was discovered that Neutrophil Extracellular Traps (NETs) may be involved in the inflammatory process of this disease, as these networks of chromatin and antimicrobial peptides, expelled by neutrophilic granulocytes, can be found in psoriatic plaques and are colocalized with Interleukin 17, a keyplayer in the signal pathway of Psoriasis. Therefore, the TLR dependency of the Netosis, triggered by different activators of the Netosis, was investigated. There was no significant difference within the knock-out-mice. Furthermore a mouse model of psoriasis-like skin inflammation was established, using intradermal injections of IL-23 in Bl6 mice. NETs were shown in the early phase (day 5) of the chronic inflammation, whereas they aren´t significantly present in later phases (day 10). Proceeding this results, the therapeutical, systemic hydrolysis of DNA with DNase 1 led to a decrease in the presence of NETs, as well as the clinical reduction of inflammation. In addition to that, it seems that the NETs are locally restricted. An increased systemic NETosis during the inflammatory process wasn´t shown. The systemic application of DNase 1 doesn´t reduce the free DNA in control mice.	de
dc.contributor.coReferee	Dressel, Ralf Prof. Dr.
dc.subject.eng	Neutrophil	de
dc.subject.eng	Extracellular	de
dc.subject.eng	Traps	de
dc.subject.eng	NET	de
dc.subject.eng	NETosis	de
dc.subject.eng	Psoriasis	de
dc.subject.eng	Interleukin-23	de
dc.subject.eng	psoriasis-like	de
dc.subject.eng	inflammation	de
dc.subject.eng	NETs	de
dc.identifier.urn	urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-58A9-7-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Dermatologie / Venerologie - Allgemein- und Gesamtdarstellungen (PPN619876174)	de
dc.description.embargoed	2021-08-03
dc.identifier.ppn	1762936240

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Human- und Zahnmedizin [2880]

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