Blättern Medizin nach Betreuer & Gutachter "Alves, Frauke Prof. Dr."
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Extending the classical histological routine through microcomputed tomography imaging and multimodal image processing
(2024-04-08)Histological analysis has proven to be the de facto gold standard for the characterization of hard and soft tissue samples at cellular resolution in both clinical routine and biomedical research. After the tissue sample ... -
Fibroblasts in colorectal cancer: Subtype diversity and immune cell modulation
(2024-02-20)Despite significant advances in early detection and treatment, colorectal cancer (CRC) remains one of the deadliest cancers worldwide. In case of advanced disease, immunotherapies, such as immune checkpoint inhibitors ... -
Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
Evaluation der Gewebeperfusion des mikrozirkulären Systems mit Hilfe von hyperspektraler Bildgebung nach Majoramputation an der unteren Extremität
(2023-09-11)Introduction: Perfusion disorders are a frequent complication after major amputation at the lower limb. The resulting decreased tissue perfusion and venous stasis lead to wound healing disorders and tissue necrosis as well ... -
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Vorbereitende Studien zu Methoden der Wachstumslenkung am Schafsmodell
(2023-08-03)In the present work, investigations were carried out within the framework of the BMBF project "Externally steerable plate osteosynthesis system for children (KiD Plate)" (No.13GW0302B). The investigations concerned the ... -
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
(2023-03-09)Microvascular dysfunction is a pathological hallmark of the diabetic myocardium, and is central to the etiology of diabetes-associated cardiac events. Herein, previous studies highlighted the role of the vasoactive micro-RNA ... -
Der Einfluss von Rab5c auf die Ciliogenese bei chondrogenen Progenitorzellen
(2023-02-15)The primary cilium is gaining increasing importance in research because it is believed that the primary cilium is involved in regulating the differentiation, matrix synthesis potential, and migration of chondrogenic ... -
Auswirkung von ACE-Hemmern auf die Nierenfunktion bei hereditären Nierenerkrankungen wie dem Alport-Syndrom im Mausmodell
(2022-04-22)Alport syndrome is a hereditary kidney disease that leads to the development of progressive kidney failure. It is based on mutations in the COL4 genes. Homozygous or hemizygous patients develop the disease earlier and more ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
Cartilage Adjacent Subchondral Bone in Ageing and Disease as a Diagnostic and Therapeutic Target
(2021-05-06)Osteochondral unit is emerging as a focal point in osteoarthritis (OA) research, with subchondral bone (SB) attracting more attention as a critical contributing factor to the initiation and progression of OA. In particular, ... -
Cellular immunotherapy of pancreatic ductal adenocarcinoma: Discovery and evaluation of novel target candidates
(2021-03-19)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have achieved remarkable success in the ... -
Evaluation der Interaktionen zwischen extrazellulärer Matrix und ausgewählten tumorassoziierten Proteinen mittels Nahinfrarot-Antikörpern
(2020-10-23)The interplay between tumor cells and their microenvironment is crucial for carcinogenesis and tumor progression. In my thesis, I examine selected tumor-associated proteins that interact with the extracellular matrix ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Untersuchungen zur Chemotherapieresistenz von H8N8-Tumorzellen nach Cyclophosphamid-, Doxorubicin- und 5-Fluouraciltherapie im syngenen WAP-T-Mammakarzinom-Mausmodell
(2019-10-18)In breast cancer patients, it is usually not the primary tumor that is the cause of death, but rather the development of locoregional or distant recurrence. Despite seemingly complete resection, some tumor cells often ... -
Die Wirkung des kompetitiven Gastrin-releasing peptide-(GRP-) -Antagonisten RC 3095 auf das Wachstumsverhalten im Modell experimentell induzierter orthotoper Nierenzellkarzinome – Analyse mittels Volumencomputertomographie (VCT)
(2017-08-21)Despite the use of new drugs, renal tumours are still difficult to treat during the metastatic stage and have an unfavourable prognosis. Consequently, it makes sense to study new therapeutic paths in an animal model. In ... -
Development and evaluation of new approaches for fluorescence-guided surgery and therapy of pancreatic ductal adenocarcinoma using orthotopic mouse models
(2017-07-11)Pancreatic cancer has the poorest survival rate of the most common types of cancers with a 5 year survival rate of only 3-5% after diagnosis. Since there has been no significant improvement in the clinical outcome for ... -
Analyse von Mikrosatelliteninstabilität und hMSH2-Expression bei Patienten mit akuter myeloischer Leukämie
(2017-06-12)Acute myeloid leukemia, the most common acute leukemia in adults, is a malignant, genetically heterogeneous, clonal disorder, which is based on haemopoietic progenitor cells with a disrupted ability of self-renewal, ...