Dokumente Zentren & Graduiertenschulen nach Erscheinungsdatum
Anzeige 21-40 von 1254
-
Multi-omics studies of transcription regulatory mechanisms during human cell fate transition
(2024-02-16)RNA polymerase II (Pol II) transcription is an essential process in living organisms that requires accurate regulation and coordination in order to produce protein-coding and many types of non-coding transcripts. One of ... -
The Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel in Sharp Wave Ripples, Place Cells, and Spatial Memory
(2024-02-09)Previous research in our lab found impaired long-term potentiation (LTP) of CA3-CA1 synapses, a fundamental process for learning and memory, in transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice. The TRPV1 ... -
Bayesian Structural Ensemble Determination from Single-Molecule X-ray Scattering
(2024-02-09)Single-molecule X-ray scattering experiments using ultrashort X-ray free electron laser (XFEL) pulses have opened a new route for the structure determination of biomolecules. They also hold the potential to extract the ... -
Functional characterization of protease inhibitors involved in induced systemic defenses in poplar
(2024-02-05)Plants are constantly challenged with biotic stresses. Stresses are gaining importance due to climate change, where extended periods of warmer conditions are expected globally. Extended warmer temperatures also mean longer ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Mechanisms underlying postoperative pain – A translational study
(2024-02-05)The current focus on pain following surgery is in understanding the mechanisms behind it to develop methods to reduce its impact in patients. Surgery is necessary for treating several diseases and conditions; therefore, ... -
Mechanistic Investigation of the Mode of Action of the Antimicrobial Peptide Lugdunin in Lipid Membranes
(2024-01-26)Dissemination of infections originating from antibiotic-resistant bacteria constitutes an escalating threat to global healthcare systems further compounded by the stagnant development of novel antibiotics. Therefore, the ... -
Neural network integration from multimodal imaging in epilepsy and healthy controls
(2024-01-17)Different imaging modalities can be used to probe distinct aspects of the brain, such as cerebral anatomy (MRI), tissue diffusion directions (DTI), metabolic activity (PET), neurovascular activity (fMRI), or electrophysiological ... -
Comparative genome and phenotypic analysis of Clostridioides difficile strains
(2024-01-16)The anaerobic bacterium Clostridioides difficile, renamed from Clostridium difficile, substantially accounts for nosocomial, antibiotic-associated infections worldwide. The complex dynamics of various traits shape the ... -
Collective Behaviour of Filamentous Cyanobacteria
(2024-01-11)Cyanobacteria are the oldest phototrophic organisms on the planet. Having been responsible for the “Great Oxidation Event” millions of years ago, it has enabled the development and sustenance of multi-cellular life forms, ... -
Non-equilibrium Statistical Mechanics Studied Through the Lens of Stochastic Calculus
(2024-01-11)The microscopic world of atoms and molecules is continuously in motion, which is manifested on the macroscopic scale as a non-zero temperature. Due to collisions with surrounding molecules that perform thermal motion, many ... -
CFM: Confinement Force Microscopy-a dynamic, precise and stable microconfiner for traction force microscopy to study confined cell behaviour
(2024-01-11)Physical properties of the 3D microenvironment and the residing tissue affect cell behavior and function. 3D environment represents major physical obstacles for cell migration, such as spatial confinement, which could ... -
Influence of Interictal Epileptiform Activity on Language Networks in Children with Rolandic Epilepsy or Dyslexia
(2024-01-05)Self-limited Epilepsy with Centrotemporal Spikes (SeLECTS) is the most common genetic epilepsy in children. It is characterized by seizures remission in puberty and highly frequent interictal epileptiform discharges (IEDs) ... -
Phase Separation Studied by Nuclear Magnetic Resonance
(2024-01-04)Signal transduction by the ligated B cell receptor (BCR) depends on the pre-organization of its intracellular components, such as the effector proteins SLP65 and CIN85 within phase-separated condensates. These liquid-like ... -
Information, Logic, and Inference in the Analysis of Complex Networks
(2023-12-22)This thesis deals with a range of current topics in information theory and statistics. It consists of five distinct contributions: Chapter 2 focuses on the statistics of single-regression Granger causality estimators. ... -
A comprehensive study of the adult mouse brain transcriptome: analysis of inter-individual differences in cognitive aging and cell-type specific changes in the hippocampus upon voluntary exercise
(2023-12-19)The hippocampus (HPC) is a brain region crucial for learning and memory processes, and this link between the HPC and cognition has been extensively studied in recent decades. Previous research has demonstrated that external ... -
The evolution of the head appendages in marine bristle worms
(2023-12-15)Annelida can be found in all kind of habitats and thus show a huge diversity in form, size, and colour. A key structure for their evolutionary success and adaptability to their individual lifestyles are the head appendages. ... -
Structural studies of RNA polymerase II complexes with human TFIIS and capping enzymes
(2023-12-14)Transcription is a conserved fundamental cellular process carried out by RNA polymerases (Pol) that results in the synthesis of an RNA transcript. Transcription of protein coding genes by Pol II is the first step in ... -
Functions of cytoplasmic lattices in mammalian oocytes and embryos
(2023-12-12)Preimplantation embryogenesis is dependent on maternally stored proteins, transcripts, and other macromolecules. Although this is a well-established dogma, it is unclear how mammalian oocytes store maternal factors needed ... -
Neural correlates of action effects anticipation – towards ecological more relevant paradigms
(2023-12-07)Imagine it is Saturday morning and you are going for groceries with your car. Once you arrive at the supermarket, you attempt to reverse park your car in a narrow parking space. You have learned in school, if you want ...