Blättern nach Typ "cumulativeThesis"
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Exakte Methoden zur Analyse von Changepoints in binomial-verteilten Sequenzen mit verbesserter Power bei kleinen Fallzahlen
(2024-05-03)Several asymptotic and exact methods exist to detect a change in a sequence of independent binomial random variables. Whenever the sample size or the event rate is small, asymptotic methods may suffer from type I error ... -
Extending the classical histological routine through microcomputed tomography imaging and multimodal image processing
(2024-04-08)Histological analysis has proven to be the de facto gold standard for the characterization of hard and soft tissue samples at cellular resolution in both clinical routine and biomedical research. After the tissue sample ... -
Molekulare und elektrophysiologische Untersuchung der Exozytose in der Maus-Cochlea
(2023-12-20)The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, I studied the role of Rab3 ... -
Gesundheitsbezogene Lebensqualität von Kindern, Jugendlichen und Erwachsenen nach einem Schädel-Hirn-Trauma
(2023-12-07)Traumatic brain injury (TBI) is considered as a major burden on public healthcare systems worldwide. The negative consequences of TBI might affect various aspects of people’s lives, leading to enormous negative effects on ... -
Physical activity and developmental psychopathology in children and adolescents: cross-sectional, longitudinal follow-up and concurrent developmental relationships
(2023-09-26)The current cumulative dissertation aimed to investigate the cross-sectional and longitudinal relationships between mental health problems, including symptoms of ADHD, and physical activity (PA) in children and adolescents. ... -
Klinische und polysomnografische Charakteristika von Patienten mit Restless-Legs-Syndrom unter Augmentation
(2023-05-30)Restless legs syndrome (RLS), as a circadian movement disorder, can have a high impact on the quality of sleep and everyday life. For RLS-treatment multiple substances including dopamine agonists are recommended in the ... -
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
(2023-05-02)Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, ... -
Methods for Blinded Sample Size Recalculation in Adaptive Enrichment Designs
(2022-12-21)In precision medicine the potential heterogeneity of patient populations becomes more accessible through technical and medical innovations. A population might be heterogeneous and different strata may in turn respond ... -
Extracellular vesicles derived from adipose mesenchymal stem cells (AMSCs) reduce autophagic flux via microRNA-25-3p transfer after ischemic stroke
(2022-03-03)Causal therapy of ischemic stroke remains available to only a minority of patients despite the success of systemic thrombolysis and thrombectomy. Consequently, new adjuvant therapeutic options are urgently needed. MSC ... -
Ethische Implikationen der Prädiktion und Früherkennung einer Late-onset-Demenz
(2021-06-24)The focus on diagnosing dementia as early as possible has entered clinical practice, often supported by the use of an increasing number of available biomarkers. New diagnostics in this topic area are the subject of intense ... -
Blinded Sample Size Re-estimation for Longitudinal Overdispersed Count Data in Randomized Clinical Trials with an Application in Multiple Sclerosis
(2021-02-22)In many clinical experiments, particularly in randomized clinical trials, the sample size required needs to be assessed and justified. For calculating a clinical trial’s sample size, assumptions have to be made regarding ... -
Chlamydien und Gonokokken – mehr als Erreger der weltweit häufigsten sexuell-übertragbaren Infektionen? Bindung antibakterieller Antikörper an Proteine des humanen fetalen Gehirns – Molekulare Identifizierung und funktionelle Charakterisierung zellulärer Interaktionspartner
(2020-09-22)Neisseria gonorrhoeae and Chlamydia trachomatis are the bacterial pathogens of the most common sexually transmitted infections worldwide. The clinical presentation of the infections is variable. A large number of patients ... -
Über den neurenterischen Kanal im Embryo des Menschen und des Neuweltaffen Callithrix jacchus
(2020-06-19)The existence of the neurenteric canal and its potential influence on fetal malformations such as neuroendodermal cysts, junctional neurulational defects and split notochord syndrome has been discussed by embryologists and ... -
Planung multizentrischer randomisierter klinischer Studien mit kontinuierlichem Endpunkt
(2020-03-31)Multicentre controlled randomized clinical trials are a cornerstone of modern evidence-based medicine. The benefits of collecting data from more than one centre are numerous, including accelerated recruitment and better ... -
Apheresis therapy in immunopathologically classified multiple sclerosis patients
(2020-01-31)Plasma exchange and immunoadsorption are second-line apheresis therapies for steroid-unresponsive multiple sclerosis relapses with a variable response rate. The mechanism of action of these therapies is assumed to be the ... -
The role of N-terminal pro-B-type natriuretic peptide in psychosocial functioning of depressed coronary heart disease patients
(2019-12-11)Patients suffering from coronary heart disease (CHD) are often affected by mental health issues, such as depression, anxiety and low quality of life. This affects the progression of their heart condition negatively. ... -
Der Einfluss von Knochenrekonstruktionstechniken auf die implantologische Rehabilitation bei Kontinuitätsdefekten des Unterkiefers
(2019-09-19)Computer-aided design/manufacturing (CAD/CAM) is now widely used, but whether it can help to overcome complications in mandibular reconstruction and accelerate dental implantation is still a matter for debate. Therefore, ... -
Comorbid sleep problems and dysregulation profile from childhood to adolescence – longitudinal course, concurrent development and reciprocal relationship
(2019-05-23)The present cumulative dissertation examined a clinically relevant topic, namely difficulties of sleep and self-regulation from early childhood to adolescence about their longitudinal association, concurrence and reciprocal ... -
Lehrqualität in der universitären Medizin
(2019-05-08)Background: In undergraduate medical education, teaching quality needs to meet high standards because teaching represents a fundamental component in the training of future physicians. For this, student ratings of teaching ... -
Die Verordnung von Schlaf- und Beruhigungsmitteln: Ein Mixed-methods-Ansatz zur Exploration einer Drucksituation
(2018-12-18)Background. Benzodiazepines and Z-drugs are frequently prescribed for more extended periods than recommended despite the potential risks for patients. To identify a lack of knowledge as a crucial factor would be insufficient. ...