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Der Einfluss von Neuregulin-1 auf die Remyelinisierung im peripheren Nervensystem

dc.contributor.advisorSereda, Michael Werner Prof. Dr.
dc.contributor.authorStassart, Ruth Martha
dc.date.accessioned2013-09-05T09:32:23Z
dc.date.available2013-09-18T22:50:05Z
dc.date.issued2013-09-05
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0001-BB5C-8
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4013
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleDer Einfluss von Neuregulin-1 auf die Remyelinisierung im peripheren Nervensystemde
dc.typedoctoralThesisde
dc.title.translatedThe role of neuregulin-1 in peripheral nervous system remyelinationde
dc.contributor.refereeSereda, Michael Werner Prof. Dr.
dc.date.examination2013-09-10
dc.description.abstractengThe peripheral nervous system demonstrates an exceptional plasticity after nerve injury and Schwann cells remyelinate newly regenerated axons. However, myelin sheath thickness does not reach its original thickness and axons remain hypomyelinated after injury. During peripheral nerve development, the transmembrane growth factor neuregulin-1 type III is expressed on the axonal surface and regulates Schwann cell development as well as myelin sheath thickness. After peripheral nerve injury, Wallerian degeneration is induced and Schwann cells remain without axons and, hence, axonal neuregulin-1 type III stimulation. We demonstrate that during this time period, denervated Schwann cells strongly induce the expression of the paracrine type I isoform of neuregulin-1 which is barely detectable in non-injured nerves. Mutant mice with a specific deletion of the neuregulin-1 gene in Schwann cells are fully myelinated during development, but exhibit impaired remyelination after experimental peripheral nerve injury. We suggest a model in which loss of axonal contact triggers denervated Schwann cells to transiently express neuregulin-1 as an endogeneous signal that promotes Schwann cell redifferentiation and remyelination.de
dc.contributor.coRefereeSimons, Mikael Prof. Dr.
dc.contributor.thirdRefereeOppermann, Martin Prof. Dr.
dc.subject.gerNeuregulin-1de
dc.subject.gerPeripheres Nervensystemde
dc.subject.gerRemyelinisierungde
dc.subject.gerSchwannzellede
dc.subject.engneuregulin-1de
dc.subject.engperipheral nervous systemde
dc.subject.engremyelinationde
dc.subject.engSchwann cellde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0001-BB5C-8-4
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizinde
dc.description.embargoed2013-09-18
dc.identifier.ppn767427386


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