Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and
limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have
achieved remarkable success in the ...
Based on a high degree of cellular plasticity and triggered by external (e.g. inflammation) or internal (e.g. oncogenic pressure) signals, pancreatic acinar cells can undergo reprogramming processes resulting in acinar-to-ductal ...
Several cytokines mediate cellular responses via the family of transcription factors called signal transducers and activators of transcription (STAT). Though phosphorylated STATs (P-STAT) form the active and extensively ...
Cardiac function is defined by the process of excitation and contraction. During this process, the electrical excitation of the surface membrane is coupled to Ca2+-ion release at the sarcoplasmic reticulum, resulting in ...
The world’s population is ageing rapidly. Currently, people at the age of 60 and over represent 12.3% of the global population. By 2050, this number will rise to almost 22%. Our knowledge of ageing underlying processes is ...