The importance of elucidating mechanisms of cardiac regulatory networks during cardiogenesis is underscored by the re-activation of fetal gene expression in the diseased adult heart. To further understand this phenomenon, ...
Hodgkin lymphoma (HL) is a unique entity where the fraction of malignant cells accounts for only 1 % of the tumor. The cells are embedded in a complex background of non-neoplastic immune infiltrates. Profound interactions ...
Autophagy is a degradative pathway that is conserved from yeast to mammals. Marcoautophagy is characterized by the formation of a unique double-membrane layered vesicle, the so-called autophagosome. Proteins and organelles ...
CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ...
Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin tumor in humans with increasing incidence. cSCC is a result of malignant transformation of epidermal cells with ultraviolet (UV) radiation ...