Myofibroblasts are crucial for normal wound healing and tissue remodelling and play an es-sential role in the pathogenesis of ischemic tissue fibrosis. Due to their contractile features, myofibroblasts support wound closure; ...
Biological causes of many human diseases can be understood more comprehensively by measuring molecular states of the cells. Characterization of cells based on their inherent molecular profiles as well as functional changes ...
Heart failure (HF) is the pathologic inability of the heart to supply the body with sufficient amounts of oxygen-rich blood. This increasingly common, life-threatening condition occurs in the final stage of various cardiac ...
Background: The aim of the presented thesis was to analyze the activation of the monomeric G protein RhoA in adult cardiomyocytes and further to unravel the role of the guanine nucleotide exchange factor p63RhoGEF in this ...
Nucleophagy is a specific type of autophagy, a process for the degradation of non-essential parts of the nucleus under starvation conditions. Nucleophagy can be subdivided into Atg39 and Atg40 dependent macronucleophagy ...