Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ...
Cardiac contraction and relaxation depend on intracellular Ca2+ release and sequestration in the sarcoplasmic reticulum (SR). The small tail-anchored protein phospholamban (PLN) is essential for normal stress-adaptation ...
Malignant melanoma is the deadliest form of skin cancer. Due to its genetic heterogeneity and
high potential to metastasize, the treatment of melanoma is challenging. Despite the promising
result of T-cell based therapeutic ...
The DNA molecule stands at the center of cancer origin and treatment. Cancer cells are addicted to DNA mutations and DNA replication, therapeutic non-responders are often based on the rate of mutations and ability to ...
Adenoviruses (AdV) are DNA viruses that replicate in the nucleus of their host cell. Due to the limited coding capacity, they have to take advantage of cellular mechanisms in order to perform their infection cycle. During ...