Molekulare Medizin
Recent Submissions
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Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
Analysis of JCPy virus spread in human CNS tissue and establishment of PML models
(2023-12-07)Progressive multifocal leukoencephalopathy (PML) is a demyelinating CNS disease caused by the reactivation of the JC polyomavirus (JCPyV) in immunosuppressed individuals. The disease course is typically severe and in up ... -
Dynamics of the microbiome in pancreatic cancer from inception to invasion
(2023-10-23)Recently, the microbiome was associated with hallmark features of pancreatic ductal adenocarcinoma (PDAC). This dismal human disease with one of the lowest survival rates of below 10% is characterized by clinical challenges ... -
Defining the Role of Chromatin Remodeling Complexes in Control of Master Transcription Factor Networks in Pancreatic Cancer Subtype Switch
(2023-10-19)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease characterized by a dismal prognosis of 11%, projected to be the second-leading cause of cancer-related death by 2040. This urgent clinical challenge ... -
Spatial Architecture and Functional Characterization of Super Enhancer Associated Transcriptional Circuits in Aggressive Lymphomas
(2023-10-19)Aggressive lymphomas are clinically and biologically heterogenous entities, reflecting a diverse cell of-origins with multiple means of malignant transformation. With chemoimmunotherapy, a majority of patients suffering ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Impaired chromosome integrity caused by mutations in members of the BTRR complex
(2023-10-17)Bloom syndrome (BS) is an autosomal recessive rare disorder clinically characterized by primary microcephaly, growth deficiency, short stature, photosensitivity, immunodeficiency, and cancer predisposition. BS is caused ... -
Comparative analysis of the mitochondrial proteome in a mouse model of Rett syndrome
(2023-10-12)Rett syndrome is a neural development disorder. The gene, for culprit protein, MeCP2 (methylated CpG binding protein) is located on chromosome X and the majority of patients are young girls. Rett syndrome patients do not ... -
Mitochondrial nucleoid distribution and its relation to presynaptic activity investigated by correlative light microscopy
(2023-10-11)Mitochondria are essential for eukaryotic life, because they provide most of the energy for a variety of cellular processes. Especially high energy demanding cells and tissues like the muscles and the neuronal cells of the ... -
Knockdown of NEAT1 prevents lipid droplet accumulation in microglia after ischemic stroke via autophagy
(2023-10-06)Lipid droplets (LDs), lipid-storing organelles containing neutral lipids such as glycerolipids and cholesterol, are increasingly accepted as structural markers of inflammation. The nuclear paraspeckle assembly transcript ... -
Characterization of myelin-specific autoantibodies in an EAE mouse model
(2023-10-02)Abstract Autoimmune diseases are caused by an attack of the immune system against own tissues, but the exact effector mechanisms may vary between individual diseases and are not yet fully understood. The autoimmune disease ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
High throughput strategies for electrophysiological characterisation of cardiomyocytes
(2023-08-22)Personalised medicine describes the customised application of medical treatment at a patient-specific level. This type of precision medicine stratifies patients based on their specific genotype or phenotype for targeted ... -
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Alpha-synuclein-associated alterations at the synapse in models of Parkinson’s disease
(2023-08-16)Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is characterized by the typical motor features, and also by a multiplicity of non-motor symptoms. The main pathological hallmarks of PD ... -
Modulation of HSF1 activity by p53 and its impact in cancer therapies
(2023-07-13)The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ... -
Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
The Role of Heat Shock Protein A4 (HSPA4) in the Heart
(2023-07-07)Non-ischemic cardiomyopathies may be caused by genetic mutations but may also result from cytotoxic influences of chemotherapeutic drugs and the accumulation of misfolded proteins. Heat shock protein A4 (HSPA4) ... -
TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
Atrial mitochondrial calcium handling in patients with atrial fibrillation
(2023-05-30)Atrial fibrillation (AF) is the most common form of arrhythmia however, due to the incomplete understanding of its molecular mechanisms, there are several limitations of the currently available therapeutic strategies. ...