Browsing Molekulare Medizin by Title
Now showing items 1-20 of 258
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3D imaging of immune cell reaction in pancreatic cancer organoids: the response to a nanovaccine therapy
(2024-06-27)This PhD thesis explored the use of patient-derived organoids (PDOs) obtained from tumor tissue, to address research limitations and therapeutic challenges in pancreatic ductal adenocarcinoma (PDAC), characterized by a ... -
A cell-type and compartment specific analysis of glutathione and hydrogen peroxide
(2019-07-04)Reactive oxygen species (ROS) have been recognized to play important roles as messenger molecules. They are involved in the etiology and progression of cardiovascular diseases such as myocardial infarction, cardiac hypertrophy ... -
Aberrant CDK1 Activity in S Phase Induces Chromosomal Instability by Increasing Mitotic Microtubule Polymerisation Rates in Colorectal Cancer Cells
(2021-05-27)Whole chromosomal instability (W-CIN), one of the major hallmarks of human cancer, is defined as the perpetual gain or loss of whole chromosomes during mitosis leading to the development of heterogeneous karyotypes. W-CIN ... -
Airway Epithelial Cells as Targets of Glucocorticoid Therapy in Inflammatory Lung Diseases
(2017-02-24)Glucocorticoids (GCs) have been a mainstay in the treatment of various autoimmune and allergic diseases for many decades due to their potent anti-inflammatory activities. The beneficial effects of GCs are mediated by the ... -
Alpha-Actinin-4 Supports B Cell Survival by Limiting Lateral BCR Mobility
(2023-10-17)The B cell antigen receptor (BCR) is involved in many cellular processes that define B cell fate. Once engaged by a cognate antigen, the BCR initiates a series of signaling cascades that drive B cell activation, proliferation, ... -
Alpha-synuclein-associated alterations at the synapse in models of Parkinson’s disease
(2023-08-16)Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is characterized by the typical motor features, and also by a multiplicity of non-motor symptoms. The main pathological hallmarks of PD ... -
Amyloid beta 4-42 in Alzheimer’s disease: Target, Therapy, Mechanism
(2016-04-14)Targeting Aβ has recently been the main objective in Alzheimer’s disease therapeutic approaches. Passive immunization trials have encountered undesirable side effects but the therapy remains a promising option. Aβ4-x has ... -
An integrated approach using patient-specific induced pluripotent stem cells and protein biochemistry to study Vici syndrome associated cardiomyopathy
(2016-10-17)Vici syndrome is a rare autosomal recessive inherited multisystem disorder caused by mutations in EPG5. More than 80% of the patients with Vici syndrome suffer from cardiomyopathy. In this study, the induced pluripotent ... -
An integrative and translational assessment of altered atrial electrophysiology, calcium handling and contractility in patients with atrial fibrillation
(2020-11-18)Atrial fibrillation (AF) is the most prevalent sustained arrhythmia reported in clinical practice, and it is associated with deleterious outcomes such as stroke, that increase patient morbidity and mortality. Previous ... -
Analyse molekularer Marker und Signalwege in soliden Tumorzelllinien und ihre Bedeutung für die Tumorprogression und Metastasierung
(2016-06-01)The development of distant metastases is the main leading cause of cancer death and the crucial adverse event in cancer progression. The “Seed and Soil” hypothesis by Stephen Paget states that different cancer cells prefer ... -
Analyses on the mechanisms underlying the leupaxin-mediated progression of prostate cancer
(2015-08-19)The focal adhesion protein leupaxin (LPXN) is overexpressed in a subset of prostate cancers (PCa). Recently, LPXN was shown to be involved in the progression of prostate carcinomas. In the present study, the LPXN-mediated ... -
Analysis of JCPy virus spread in human CNS tissue and establishment of PML models
(2023-12-07)Progressive multifocal leukoencephalopathy (PML) is a demyelinating CNS disease caused by the reactivation of the JC polyomavirus (JCPyV) in immunosuppressed individuals. The disease course is typically severe and in up ... -
Analysis of the function of the IGF1R during the development and therapy of colorectal cancer
(2016-12-06)The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that is overexpressed in a variety of human malignancies, including colorectal cancer (CRC). In the present study, the role of the IGF1R during ... -
Analysis of the GPCR-induced RhoA signaling in healthy and diseased adult cardiomyocytes
(2019-04-10)Background: The aim of the presented thesis was to analyze the activation of the monomeric G protein RhoA in adult cardiomyocytes and further to unravel the role of the guanine nucleotide exchange factor p63RhoGEF in this ... -
Analysis of the organization and signaling capacity of the membrane IgE during its interaction with CD19 and CD23 in B lymphocytes
(2021-07-27)The predominant allergy type I (hypersensitivity reaction type I) poses an increasing health issue in industrialized countries over the last decades. A key mediator in the pathogenesis of hypersensitivity or allergic ... -
Analysis of the peroxisomal malate/aspartate and lactate/pyruvate shuttle components and their metabolic function
(2022-05-19)Peroxisomes are responsible for several metabolic processes. Among the best known functions are the breakdown of peroxides like H2O2 and the catabolism of fatty acids by α- and β-oxidation. The proper function of these ... -
Analysis of the role of Cox20 during the early steps of Cox2 biogenesis
(2016-08-24)The catalytic core of the cytochrome c oxidase (complex IV), the terminal enzyme of the mitochondrial respiratory chain, comprises three mitochondria-encoded subunits Cox1, Cox2 and Cox3 that are highly conserved among ... -
Analyzing the effects of laquinimod on innate and adaptive immunity in mice with experimental autoimmune encephalomyelitis
(2014-05-09)Laquinimod (LAQ), a new orally active immunomodulator, is currently under investigation for the treatment of multiple sclerosis (MS). In clinical trials LAQ considerably reduced the annualized relapse rate, disability ... -
Antibody-mediated initiation and lymphocyte-targeting therapies in CNS demyelinating disease
(2019-07-22)Multiple sclerosis is inflammatory central nervous system disease, characterised by areas of demyelination and axonal loss. The pathogenic mechanism behind the disease still remains unknown, however it is thought to be ... -
Application of redox biosensor mouse models to study redox processes in cardiomyocytes
(2019-08-08)Reactive oxygen species (ROS) are highly reactive molecules produced in any biological system. When ROS are produced in higher amounts, they are lethal to cells. Therefore cells possess a tight redox regulation through ...