dc.contributor.advisor | Christiansen, Hans Prof. Dr. | de |
dc.contributor.author | Wolff, Cornelia Ruth Marie | de |
dc.date.accessioned | 2013-01-14T15:17:47Z | de |
dc.date.available | 2013-01-30T23:50:51Z | de |
dc.date.issued | 2012-05-16 | de |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-000D-EFAF-8 | de |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-1520 | |
dc.description.abstract | Durch eine Vielzahl von Studien und
Literaturnachweisen ist bekannt, dass Patienten mit den
Risikofaktoren Nikotin- und Alkoholabusus ein deutlich erhöhtes
Risiko aufweisen, an malignen Tumoren zu erkranken. Dies führt zu
der Überlegung, bei diesen Patienten mittels Screeningverfahren die
Früherkennung von Tumoren zu verbessern. Dies gilt insbesondere
auch für Patienten, welche zuvor bereits kurativ aufgrund eines
Tumors im HNO-Bereich behandelt worden sind, da die heutige
multimodale Therapie immer bessere Überlebensraten ermöglicht und
gerade diese Patienten häufig entsprechende Risikofaktoren
aufweisen. Somit werden insbesondere bei diesen Patienten im
weiteren Verlauf nach kurativer Behandlung des Kopf-Hals-Tumors
zunehmend Zweittumore in der Lunge oder dem | de |
dc.format.mimetype | application/pdf | de |
dc.language.iso | ger | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | de |
dc.title | Inzidenz von Zweittumoren bei Patienten mit zuvor kurativ behandeltem Tumor im Hals-Nasen-Ohren-Bereich - eine prospektive Analyse | de |
dc.type | doctoralThesis | de |
dc.title.translated | Incidence of secondary malignant tumors in patients with curatively treated head and neck cancer - a prospective analysis | de |
dc.contributor.referee | Christiansen, Hans Prof. Dr. | de |
dc.date.examination | 2012-05-22 | de |
dc.subject.dnb | 610 Medizin, Gesundheit | de |
dc.subject.gok | MED 424 | de |
dc.description.abstracteng | Patients treated previously for a head and
neck squamous cell carcinoma (HNSCC) carry a high-risk for second
malignant tumors, particularly for other head and neck tumors, lung
cancer and esophageal cancer. The main risk factors for the
development of such malignancies are widespread agents like tobacco
smoking often in combination with abuse of alcohol. Since the
long-term outcome of patients with HNSCC has improved through
optimized multimodal approaches including surgery,
radio(chemo)therapy, or combination of both, the incidence of
subsequent cancers has become a life-limiting factor. The present
study evaluated the potential benefit of a CT of the chest, an
endoscopy of the esophagus and stomach and an ear-nose-throat
endoscopy for early detection of second malignant tumors for HNSCC
patients at high-risk. Therefore, between 07/2008 and 11/2011
participants underwent a systematic examination for second
malignant tumors. All patients had been treated for a HNSCC 1 to
140 months before examination and showed no loco-regional relapse
or distant metastases, so far. Overall, 118 consecutive patients
were recruited. In total 33 suspicious findings were clarified by
additional investigations. By these procedures, 26 second malignant
tumors were confirmed within 21 patients (10 lung, 7 head and neck,
3 gastrointestinal, 1 renal tumor(s)). Subsequently, 18 of these 21
patients (86%) could be treated again in curative intent. In
summary we found a high prevalence of curable second malignant
tumors in a defined subgroup of patients at high-risk with prior
HNSCC. All tumors were asymptomatic at the point of examination and
were mostly detected in an early tumor stage, which may lead to a
lower rate of tumor dependent mortality. To proof a lower rate of
mortality prospective multicenter long-term studies are
necessary. | de |
dc.contributor.coReferee | Hommerich, Christian Prof. Dr. | de |
dc.subject.topic | Medicine | de |
dc.subject.ger | HNO-Tumor | de |
dc.subject.ger | Risikofaktoren | de |
dc.subject.ger | Nikotin | de |
dc.subject.ger | Alkohol | de |
dc.subject.ger | Zweittumor | de |
dc.subject.ger | Bronchialkarzinom | de |
dc.subject.ger | Oesophaguskarzinom | de |
dc.subject.ger | CT-Thorax | de |
dc.subject.ger | Gastroskopie | de |
dc.subject.ger | Screening | de |
dc.subject.ger | Früherkennung | de |
dc.subject.eng | head and neck cancer | de |
dc.subject.eng | HNSCC | de |
dc.subject.eng | risk factor | de |
dc.subject.eng | nicotine | de |
dc.subject.eng | alcohol | de |
dc.subject.eng | second tumor | de |
dc.subject.eng | lung cancer | de |
dc.subject.eng | esophageal cancer | de |
dc.subject.eng | CT-Thorax | de |
dc.subject.eng | gastroscopy | de |
dc.subject.eng | screening | de |
dc.subject.eng | early diagnosis | de |
dc.subject.bk | 44.64 | de |
dc.identifier.urn | urn:nbn:de:gbv:7-webdoc-3506-0 | de |
dc.identifier.purl | webdoc-3506 | de |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.identifier.ppn | 72053559X | de |