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Assoziation von Höhe der antipsychotischen Medikation über die Zeit mit Kognition unter Berücksichtigung des Geschlechts

dc.contributor.advisorEhrenreich, Hannelore Prof. Dr. Dr.de
dc.contributor.authorSzuszies, Christoph Johannesde
dc.date.accessioned2013-01-14T15:19:25Zde
dc.date.available2013-01-30T23:50:27Zde
dc.date.issued2012-06-04de
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-000D-EFC2-Bde
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-1539
dc.format.mimetypeapplication/pdfde
dc.language.isogerde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de
dc.titleAssoziation von Höhe der antipsychotischen Medikation über die Zeit mit Kognition unter Berücksichtigung des Geschlechtsde
dc.typedoctoralThesisde
dc.title.translatedAssociation of antipsychotic dosage amount over time with cognition in schizophrenic patients in due consideration of genderde
dc.contributor.refereeEhrenreich, Hannelore Prof. Dr. Dr.de
dc.date.examination2012-06-06de
dc.subject.dnb610 Medizin, Gesundheitde
dc.subject.gokMED550de
dc.description.abstractengBackground: Available anti-psychotic drugs failed to show a positive effect on cognitive impairment, a core symptom of schizophrenic patients. Prescribing anti-psychotics is an essential part of patient treatment. Over the duration of treatment anti-psychotic daily doses are often escalated to an extreme, trying to alleviate symptoms. Sex-differences in the course of disease, symptoms of disease, cognition and sensitivity related to anti-psychotics are known. In contrast, the strength of cognitive impairment under increasing anti-psychotic dosage over time to very high anti-psychotic daily doses is not well-established. Methods: The association of anti-psychotic dosage amount over time with cognition in patients with schizophrenia in due consideration of sex in a widespread patient sample of n=1029 (GRAS- cross-sectional study) will be investigated for the first time. Approved psychometric and neurological rating scales, detailed neuropsychological tests, structured interviews, and evaluation of early health record concerning disease outbreak are background for the analyses. The value “dose-increasede
dc.contributor.coRefereeFriede, Tim Prof. Dr.de
dc.subject.topicMedicinede
dc.subject.gerSchizophreniede
dc.subject.gerAntipsychotikade
dc.subject.gerKognitionde
dc.subject.gerKrankheitsschwerede
dc.subject.gerDosissteigerungde
dc.subject.gerGeschlechtde
dc.subject.engschizophreniade
dc.subject.engantipsychotic therapyde
dc.subject.engcognitionde
dc.subject.engdisease severityde
dc.subject.engdosagede
dc.subject.engantipsychoticsde
dc.subject.engdose-increasede
dc.subject.enggenderde
dc.subject.engsexde
dc.subject.bk44.91de
dc.identifier.urnurn:nbn:de:gbv:7-webdoc-3538-8de
dc.identifier.purlwebdoc-3538de
dc.affiliation.instituteMedizinische Fakultätde
dc.identifier.ppn730546985de


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