Populations-basierte Studie zum Phänomen der Pseudoprogression nach Radiochemotherapie bei Patienten mit malignen Gliomen; Bedeutung der Diffusions- und Perfusionswichtung in der MRT

Pseudoprogression in glioblastoma multiforme after radiation and chemotherapy, a retrospective population-based study; importance of DWI and DSC in MRI

by Joseph Cohnen
Doctoral thesis
Date of Examination:2012-11-14
Date of issue:2012-10-17
Advisor:Prof. Dr. Michael Knauth
Referee:Prof. Dr. Michael Knauth
Referee:PD Dr. Florian Stockhammer
Referee:Prof. Dr. Andrea Hille
Persistent Address: http://dx.doi.org/10.53846/goediss-1626

 

 

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Abstract

English

Pseudoprogression (PsPD) following radiation and chemotherapy in patients with Glioblastoma multiforme is difficult to distinguish from progressive disease. The aim of our study was to identify early signs of PsPD in brain MRI after standard therapy including surgery, radiation and temozolomide. Out of 74 Patients with standard therapy, we retrospectively identified 47 with early progression in MRI within the first 6 months. Patients were divided in groups of “real
Keywords: pseudoprogression; dynamic susceptibility contrast; diffusion-weighted imaging
Schlagwörter: Pseudoprogression
 
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