Botulinumtoxin-Typ A - eine Therapieoption bei überaktiven und nicht-neurogenen Blasenentleerungsstörungen (retrospektive Datenanalyse)

Zachert, Katharina

dc.contributor.advisor	Loertzer, Hagen PD Dr.	de
dc.contributor.author	Zachert, Katharina	de
dc.date.accessioned	2013-01-20T13:04:40Z	de
dc.date.available	2013-01-30T23:51:04Z	de
dc.date.issued	2009-11-11	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-000D-F0DD-E	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3346
dc.format.mimetype	application/pdf	de
dc.language.iso	ger	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	de
dc.title	Botulinumtoxin-Typ A - eine Therapieoption bei überaktiven und nicht-neurogenen Blasenentleerungsstörungen (retrospektive Datenanalyse)	de
dc.type	doctoralThesis	de
dc.title.translated	Botulinum toxin type A - a treatment option for overactive and non-neurogenic detrusor overactivity (retrospective study)	de
dc.contributor.referee	Loertzer, Hagen PD Dr.	de
dc.date.examination	2010-01-10	de
dc.subject.dnb	610 Medizin, Gesundheit	de
dc.subject.gok	MED 471	de
dc.description.abstracteng	Objectives: Since the first therapeutic applications of botulinum toxin about 20 years ago, it has become an effective treatment for various indications including overactive and non-neurogenic detrusor overactivity. Synthesized in Clostridium botulinum, the neurotoxin inhibits the acetylcholine secretion leading to a paralysis when injected into the detrusor muscle with both urodynamic and clinical improvements. This minimally invasive treatment is positioned between ineffective anticholinergic treatment and invasive surgery. The present retrospective study examined the effectiveness of transurethral injections of botulinum toxin given in the Department of Urology, University of Goettingen. Methods: Patients (n=32) with overactive and non-neurogenic detrusor overactivity received 88 injections of botulinum toxin type A in 13 injection cycles from February 2002 until October 2008. The effects on urodynamic and clinical parameters were analyzed. Also four injection protocols for future applications were created. Results: In most cases 300 units of Botox	de
dc.subject.topic	Medicine	de
dc.subject.ger	Botulinumtoxin-Typ A	de
dc.subject.ger	Blasenentleerungsstörungen	de
dc.subject.ger	urodynamische Parameter	de
dc.subject.eng	Botulinum toxin type A	de
dc.subject.eng	detrusor overactivity	de
dc.subject.eng	urodynamic parameters	de
dc.subject.bk	44.88	de
dc.identifier.urn	urn:nbn:de:gbv:7-webdoc-2262-9	de
dc.identifier.purl	webdoc-2262	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.identifier.ppn	635339862	de

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