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dc.contributor.advisor Rodenbeck, Andrea Prof. Dr. de
dc.contributor.author Landgraf, Clara de
dc.date.accessioned 2013-05-10T08:14:59Z de
dc.date.available 2013-05-21T22:50:05Z de
dc.date.issued 2013-05-10 de
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0018-00A8-C de
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc 610 de
dc.title Die Auswirkungen von Nikotin und eines Nikotinentzugs auf polysomnografische und neuroendokrine Parameter de
dc.title.alternative Eine systematische Übersichtsarbeit de
dc.type doctoralThesis de
dc.title.translated The effects of nicotine and its withdrawal on sleep and neuroendocrine parameters de
dc.contributor.referee Raupach, Tobias PD Dr. de
dc.date.examination 2013-05-14 de
dc.description.abstracteng Nicotine and its withdrawal influence objective markers of sleep and neuroendocrine parameters. This systematic review compares current studies, investigating the effects of nicotine and its withdrawal on sleep, measured by polysomnography or actigraphy and cortisol and dopamine levels. In animal studies, nicotine had a dose-dependent effect on sleep, namely lower doses reduced REM-sleep and higher doses promoted wakefulness. Nonsmokers showed a reduction of REM-sleep after nicotine administration, while in depressed nonsmokers an improvement in sleep quality and depression was observed. The first days of withdrawal in smokers caused an increased fragmentation of sleep, which could be reduced by using nicotine replacement therapy. The only publication which studied the withdrawal a longer time, showed an increase of REM-sleep and a decrease of total sleep time. The parameters of the dopaminergic system were stable during the first hours of abstinence, but in a long-term study an increase in dopamine receptors was observed. Nicotine also led to an increased secretion of hormones of the HPA axis. During nicotine withdrawal, decreased concentrations of cortisol were measured. A lower cortisol concentration during abstinence predicted higher severty of withdrawal symptoms and may be a predictor of relapse. de
dc.contributor.coReferee Straube, Sebastian PD Dr. de
dc.subject.eng Nicotine de
dc.subject.eng Sleep de
dc.subject.eng Cortisol de
dc.subject.eng Dopamine de
dc.subject.eng Withdrawal de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0018-00A8-C-4 de
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Endokrinologie (PPN619875836) de
dc.subject.gokfull Schlafmedizin de
dc.subject.gokfull Suchtmedizin de
dc.description.embargoed 2013-05-21 de
dc.identifier.ppn 746434693 de

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