Die Auswirkungen von Nikotin und eines Nikotinentzugs auf polysomnografische und neuroendokrine Parameter

Landgraf, Clara

Eine systematische Übersichtsarbeit

dc.contributor.advisor	Rodenbeck, Andrea Prof. Dr.	de
dc.contributor.author	Landgraf, Clara	de
dc.date.accessioned	2013-05-10T08:14:59Z	de
dc.date.available	2013-05-21T22:50:05Z	de
dc.date.issued	2013-05-10	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0018-00A8-C	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3833
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3833
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3833
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Die Auswirkungen von Nikotin und eines Nikotinentzugs auf polysomnografische und neuroendokrine Parameter	de
dc.title.alternative	Eine systematische Übersichtsarbeit	de
dc.type	doctoralThesis	de
dc.title.translated	The effects of nicotine and its withdrawal on sleep and neuroendocrine parameters	de
dc.contributor.referee	Raupach, Tobias PD Dr.	de
dc.date.examination	2013-05-14	de
dc.description.abstracteng	Nicotine and its withdrawal influence objective markers of sleep and neuroendocrine parameters. This systematic review compares current studies, investigating the effects of nicotine and its withdrawal on sleep, measured by polysomnography or actigraphy and cortisol and dopamine levels. In animal studies, nicotine had a dose-dependent effect on sleep, namely lower doses reduced REM-sleep and higher doses promoted wakefulness. Nonsmokers showed a reduction of REM-sleep after nicotine administration, while in depressed nonsmokers an improvement in sleep quality and depression was observed. The first days of withdrawal in smokers caused an increased fragmentation of sleep, which could be reduced by using nicotine replacement therapy. The only publication which studied the withdrawal a longer time, showed an increase of REM-sleep and a decrease of total sleep time. The parameters of the dopaminergic system were stable during the first hours of abstinence, but in a long-term study an increase in dopamine receptors was observed. Nicotine also led to an increased secretion of hormones of the HPA axis. During nicotine withdrawal, decreased concentrations of cortisol were measured. A lower cortisol concentration during abstinence predicted higher severty of withdrawal symptoms and may be a predictor of relapse.	de
dc.contributor.coReferee	Straube, Sebastian PD Dr.	de
dc.subject.eng	Nicotine	de
dc.subject.eng	Sleep	de
dc.subject.eng	Cortisol	de
dc.subject.eng	Dopamine	de
dc.subject.eng	Withdrawal	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0018-00A8-C-4	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Endokrinologie (PPN619875836)	de
dc.subject.gokfull	Schlafmedizin	de
dc.subject.gokfull	Suchtmedizin	de
dc.description.embargoed	2013-05-21	de
dc.identifier.ppn	746434693	de

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