Einfluss höhergradiger akuter Organtoxizität während adjuvanter Radio(chemo)therapie auf die Prognose von Patienten mit lokal fortgeschrittenen Kopf-Hals-Tumoren

Daldrup, Benjamin

Eine retrospektive Analyse

dc.contributor.advisor	Christiansen, Hans Prof. Dr.	de
dc.contributor.author	Daldrup, Benjamin	de
dc.date.accessioned	2013-05-14T07:54:40Z	de
dc.date.available	2013-05-22T22:50:06Z	de
dc.date.issued	2013-05-14	de
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0019-E2D3-D	de
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3843
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-3843
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Einfluss höhergradiger akuter Organtoxizität während adjuvanter Radio(chemo)therapie auf die Prognose von Patienten mit lokal fortgeschrittenen Kopf-Hals-Tumoren	de
dc.title.alternative	Eine retrospektive Analyse	de
dc.type	doctoralThesis	de
dc.title.translated	High-grade acute organ toxicity as positive prognostic factor in adjuvant radio(chemo)therapy for locally advanced head and neck cancer	de
dc.contributor.referee	Hommerich, Christian Prof. Dr.	de
dc.date.examination	2013-05-15	de
dc.description.abstracteng	Purpose: To test for an association between high-grade acute organ toxicity during adjuvant radio(chemo)therapy (R(C)T) and treatment outcome in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Material and Methods: Institutional review board approval was obtained for this retrospective tudy. From 09/1994-10/2008, 294 HNSCC patients were treated with adjuvant R(C)T at our department. They received normofractionated (2Gy/fraction) irradiation to include associated nodal drainage sites for a cumulative dose of 60-64Gy. From 01/2002 until 12/2009, 91 patients received additional concomitant cisplatin-based chemotherapy. Toxicity during treatment was monitored weekly according to the common-toxicity-criteria (CTC);any toxicity grade CTC≥3, including mucositis, dysphagia or skin reaction, was considered high-grade acute organ toxicity. The influence of possible prognostic factors on overall survival and loco-regional control was studied by uni- and multivariate Cox regression. Results: We found a statistically significant association between high-grade acute organ toxicity and both overall survival as well as loco-regional control. Patients with CTC≥3 acute organ toxicity had a 5-year-overall-survival and loco-regional-control rate of 90% and 97%, respectively, as compared to 24% and 74% in patients without such toxicity (p<0.01). Multivariate analyses revealed that this association was independent from other factors that may influence treatment toxicity, especially concomitant chemotherapy and/or radiotherapy. Conclusion: Our data suggest that normal tissue and tumour tissue may behave similarly with respect to treatment response, as high-grade acute organ toxicity during R(C)T was associated with better outcomes in our patient population. Therefore, the hypothesis should be further analyzed on the biomolecular and clinical level and other tumor entities in prospective clinical trials.	de
dc.contributor.coReferee	Crozier, Thomas Prof. Dr. Dr.	de
dc.subject.eng	adjuvant radio(chemo)therapy, head and neck cancer	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0019-E2D3-D-5	de
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Radiologie / Bildgebende Verfahren / Ultraschall / Nuklearmedizin / Strahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585)	de
dc.description.embargoed	2013-05-22	de
dc.identifier.ppn	746434804	de

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Human- und Zahnmedizin [2878]

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