Langfristige Auswirkungen von ß-Ecdyson auf Knochen und Knorpel

Eine histomorphometrische Studie am osteoporotischen Tiermodell

Long-term effects of ß-ecdysone on bone and cartilage

by Anne Lanzer
Doctoral thesis
Date of Examination:2014-04-30
Date of issue:2014-04-17
Advisor:PD Dr. Dana Seidlová-Wuttke
Referee:PD Dr. Dana Seidlová-Wuttke
Referee:Prof. Dr. Michael Hüfner
Persistent Address: http://dx.doi.org/10.53846/goediss-4464

 

 

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Abstract

English

The major role of estrogen deficiency for pathogenesis of postmenopausal osteoporosis is well known. The phytoecdysteroid ß-ecdysone has shown bone-protective as well as bone-anabolic effects in former and mainly short-term studies. To analyze long-term effects of ß-ecdysone and evaluate its potential role in treating postmenopausal osteoporosis we used histomorphometric measurements of tibia bone and cartilage. Ovariectomized rats are a common animal model to reproduce conditions similar to those in postmenopausal osteoporosis. Following parameters were explored: thickness of joint cartilage, cortical bone, growth plate and zones, further area percentage of trabecular bone, red and yellow bone marrow as well as trabecular connectivity. Ovariectomy led to the expected serious bone loss especially in trabecular bone. There was no significant impact on cortical bone or growth plate. The administration of ß-ecdysone showed no benefit for animals that underwent ovariectomy. Only ovary-intact animals showed a significant higher trabecular bone area. In summary this study revealed only few benefits from a long-term ecdysone-application. ß-ecdysone alone seems to be unable to stop further bone loss caused by estrogen deficiency as it occurs in postmenopausal women.
Keywords: ß-ecdysone; ovariectomy; postmenopausal osteoporosis; bone; cartilage
Schlagwörter: ß-Ecdyson; postmenopausale Osteoporose; Knochen; Knorpel
 
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