Quantifizierung von Sevofluran an Anästhesiearbeitsplätzen mittels Ionenmobilitätsspektrometrie

Quantification of occupational exposure to sevoflurane in anaesthesia workplaces using multi- capillary column- ion mobility spectrometry (MCC- IMS)

by Cathrin Weigel
Doctoral thesis
Date of Examination:2014-08-11
Date of issue:2014-07-28
Advisor:Prof. Dr. Michael Quintel
Referee:PD Dr. Astrid Heutelbeck
Referee:Prof. Dr. Rainer Mausberg
Persistent Address: http://dx.doi.org/10.53846/goediss-4613

 

 

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Abstract

English

Background: Occupational exposure to sevoflurane has the potential to cause health damage in hospital personnel. Workplace contamination with the substance is mostly assessed using photoacoustic infrared spectrometry or flame ionization detector. Multi-capillary column-ion mobility spectrometry (MCC-IMS) could be an alternative technology for the quantification of sevoflurane in the room air and even be more accurate because of potentially lower detection limits. In principal other volatile anaesthetics could be detected and quantified simultaneously by using MCC-IMS. Objective: To test the hypothesis that MCC-IMS is able to detect and monitor very low concentrations of sevoflurane in a hospital setting. To evaluate the exposure of hospital personnel to sevoflurane during paediatric anaesthesia and in the post anaesthesia care unit (PACU). Design: Observational study. Setting: University Medical Centre of Göttingen in Germany: Paediatric dental surgical theatre (from June 19th 2012 until August 7th 2012); PACU (from October 27th 2009 until October 29th 2009). Main outcome measures: The limits of detection (LOD) and quantification (LOQ) of the MCC-IMS for sevoflurane and the sevoflurane exposure of hospital personnel measured by MCC-IMS and calculated as time-weighted average (TWA) values. Results: The LOD was 0.0068 ppbv and the LOQ was 0.0189 ppbv. During paediatric anaesthesia the mean sevoflurane concentration was 0,4602ppmv (0,0754 – 3,1473ppmv) with TWA values between 0,0052 and 0,0365ppmv. In the PACU the mean sevoflurane concentration was 0,0279ppmv (0,008 – 0,1702ppmv) and TWA values reached from 0,0093 to 0,0967ppmv. Conclusion: The detection and the quantification of sevoflurane by the use of MCC-IMS is possible. It is a reliable technology for monitoring sevoflurane concentrations at anaesthesia workplaces and has a particular strength in quantifying low-level contaminations of sevoflurane. The exposure of the personnel working in these areas did not exceed recommended limits and therefore adverse health effects are unlikely.
Keywords: Sevoflurane; Multi capillary column ion mobility spectrometry
Schlagwörter: Sevofluran; Ionenmobilitätsspektrometrie
 
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