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Synthesis and Investigation of Nucleobase Functionalized β-Peptide as SNAREs Model System for Membranefusion

dc.contributor.advisorDiederichsen, Ulf Prof. Dr.
dc.contributor.authorSadek, Muheeb
dc.publisherNiedersächsische Staats- und Universitätsbibliothek Göttingende
dc.titleSynthesis and Investigation of Nucleobase Functionalized β-Peptide as SNAREs Model System for Membranefusionde
dc.contributor.refereeSteinem, Claudia Prof. Dr.
dc.description.abstractengIn this work, the novel simplified SNARE-mimicking systems consisting of TMD/linker segments of the natural membrane-bound SNARE proteins (syntaxin-1A and synaptobrevin 2) with a nucleobase functionalized β-peptide (β-PNA) recognition motif were designed and synthesized. The β-PNAs allow antiparallel orientation and therefore, a fusion mechanism is addressed, that differs from the native SNARE situation. Nevertheless, the artificial TMD/linker/β-PNA constructs are surprisingly efficient in mediating membrane fusion. The β-PNA recognition motif with the linear and conformational rigid 14-helix backbone offers an especially interesting option of distance control between the vesicles. This system offers a powerful tool to control the fusion state by using different length of β-PNA. The extended β-PNA leads to hemifusion state while the shortened one induces full
dc.contributor.coRefereeJahn, Reinhard Prof. Dr.
dc.subject.engSNARE proteinde
dc.subject.engFusion distance controllingde
dc.subject.engParallel fusion systemde
dc.subject.engNucleobase functionalized β-peptidede
dc.affiliation.instituteFakultät für Chemiede
dc.subject.gokfullChemie  (PPN62138352X)de

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