Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms

Diederich, Christine

dc.contributor.advisor	Focke, Niels K. PD Dr.
dc.contributor.author	Diederich, Christine
dc.date.accessioned	2015-09-30T09:14:38Z
dc.date.available	2015-10-14T22:50:06Z
dc.date.issued	2015-09-30
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-9633-F
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5289
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5289
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms	de
dc.type	doctoralThesis	de
dc.title.translated	Investigation of structural cerebral alterations in patients with idiopathic-generalized epilepsy with special emphasis on the Janz syndrome	de
dc.contributor.referee	Paulus, Walter Prof. Dr.
dc.date.examination	2015-10-07
dc.description.abstracteng	The aim of this doctoral thesis was to investigate (micro-) structural alterations of the brain in patients with idiopathic-generalized epilepsy. 25 patients, subdivided in IGE (13) and in the subclass juvenile myoclonic epilepsy (JME, 12), as well as 44 healthy controls were scanned at a 3T MRI-Scanner at the MR Research Group Göttingen with conventional and new MRI-protocols (T1-weighted images, DTI, T1 Relaxometry and semi-quantitative magnetization transfer mapping). Using TBSS for the DTI data, a comparison between patients and healthy controls shows large changes in white matter tracts (FA reductions and MD increases). Voxel-based morphometry of the T1-weighted images, T1 Relaxometry and MT-mapping from 13 patients with IGE and 11 patients with JME compared to 38 controls does not detect significant alterations.	de
dc.contributor.coReferee	Dechent, Peter PD Dr.
dc.subject.eng	JME	de
dc.subject.eng	IGE	de
dc.subject.eng	TBSS	de
dc.subject.eng	VBM	de
dc.subject.eng	MRI	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9633-F-0
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	GOK-MEDIZIN	de
dc.description.embargoed	2015-10-14
dc.identifier.ppn	835946355

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Human- und Zahnmedizin [2873]

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