| dc.contributor.advisor | Schäfer, Katrin Prof. Dr. | |
| dc.contributor.author | Steier, Jasmin | |
| dc.date.accessioned | 2016-02-16T10:00:13Z | |
| dc.date.available | 2016-03-03T23:50:05Z | |
| dc.date.issued | 2016-02-16 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0028-86C7-B | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5515 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Effekt einer Tabakentwöhnung auf die Anzahl endothelialer Progenitorzellen und das kardiovaskuläre Risikoprofil | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Effect of smoking cessation on the number of endothelial progenitor cells and cardiovascular risk profile | de |
| dc.contributor.referee | Patschan, Daniel Prof. Dr. | |
| dc.date.examination | 2016-02-25 | |
| dc.description.abstracteng | Tobacco use is a leading cause of preventable deaths worldwide. The impact of smoking cessation has a big influence in this. Smoking results in morphological and functional changes in the vascular endothelium, the so-called endothelial dysfunction, which seem to play a crucial role in the development and progression of atherosclerosis. The aim of this study was to evaluate the effect of a systematic smoking cessation on known and new risk markers and predictors of endothelial dysfunction among a heterogeneous group of people willing to quit smoking.
For the first time, the focus of the research was directed on the number of EPC. Interestingly, already five weeks after smoking cessation a significant decrease of EPC was seen. The EPC increase in smokers can most likely be interpreted as a reactive regulation of a tobacco-induced endothelial damage and this seems to be reversible through smoking cessation. If smoking and further atherosclerotic risk factors and cardiovascular diseases directly affect the mobilization and the survival of the EPC or if they lead to an exhaustion of the stock in the bone marrow by permanent endothelial damage, is still unclear and needs to be shown in future studies.
Furthermore, it was revealed that the proatherosclerotic, inflammatory profile of each participant can be reduced by smoking cessation, especially those who already manifest cardiovascular risk factors or diseases.
Other studies need to clarify, if the findings of this research can be reproduced over longer periods and can provide further indications as to how tobacco use and smoking cessation affect endothelial structures and functions. These results are important to confirm the necessity of smoking prevention. | de |
| dc.contributor.coReferee | Meyer, Thomas Prof. Dr. | |
| dc.subject.ger | Endotheliale Progenitorzellen, ADMA, Raucherentwöhnung, kardiovaskuläre Risikofaktoren, endotheliale Dysfunktion | de |
| dc.subject.eng | Endothelial progenitor cells, ADMA, Smoking cessation, Cardiovascular risk factors, Endothelial dysfunction | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0028-86C7-B-0 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Kardiologie (PPN619875755) | de |
| dc.subject.gokfull | Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747) | de |
| dc.description.embargoed | 2016-03-03 | |
| dc.identifier.ppn | 847766802 | |