Charakterisierung von Prädiktoren rapid-progressiver Verläufe des M. Alzheimer

Bartlau, Thomas

dc.contributor.advisor	Zerr, Inga Prof. Dr.
dc.contributor.author	Bartlau, Thomas
dc.date.accessioned	2016-07-12T07:52:02Z
dc.date.available	2016-07-19T22:50:06Z
dc.date.issued	2016-07-12
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0028-87B4-D
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5745
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Charakterisierung von Prädiktoren rapid-progressiver Verläufe des M. Alzheimer	de
dc.type	doctoralThesis	de
dc.title.translated	Characterization of predictors for rapid progressive cognitive decline in Alzheimer´s Disease	de
dc.contributor.referee	Zerr, Inga Prof. Dr.
dc.date.examination	2016-07-12
dc.description.abstracteng	Alzheimer´s Disease (AD) is a neurodegenerative disorder, whose causes still have to be elucidated. The courses of the disease are heterogen, and rapid progresses were discribed. The data about risk factors and predictors of rapid progressive AD is still unclear. Cellular Prion Protein (PrPc) is a cell surface protein, especially of the neural tissue. Interactions of PrPc with the neuropathological hallmarks of AD, like Aß and its precursor proteins, as well as Tau, pTau and their metabolic pathways has been discribed recently. In a longitudal, prospective study we researched if PrPc in cerebrospinal fluid (CSF) of subjects with probable AD as well as other csf-biomarkers are suitable as predictors of rapid progressive cognitive decline in AD. We could show among others, that CSF-PrPc highly correlates negativly with cognitive decline in female subjects with APOE ε3/3 genotype and suggest, that PrPc in CSF could be a predictor of rpAD in specific cases.	de
dc.contributor.coReferee	Hilgers, Reinhard Prof. Dr.
dc.subject.eng	Alzheimer´s Disease	de
dc.subject.eng	rpAD	de
dc.subject.eng	Prion Protein	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0028-87B4-D-6
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	GOK-MEDIZIN	de
dc.description.embargoed	2016-07-19
dc.identifier.ppn	862999847

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Human- und Zahnmedizin [2873]

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