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dc.contributor.advisor Marquardt, Till Dr.
dc.contributor.author Lancelin, Camille
dc.date.accessioned 2016-10-10T14:23:36Z
dc.date.available 2016-10-10T14:23:36Z
dc.date.issued 2016-10-10
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7C1B-9
dc.language.iso eng de
dc.relation.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 570 de
dc.title Plasticity-dependent modulation of mitochondrial biogenesis determining motor neuron function and vulnerability de
dc.type doctoralThesis de
dc.contributor.referee Brose, Nils Prof. Dr.
dc.date.examination 2015-09-29
dc.description.abstracteng Axon terminals are likely the compartments of highest energy demand in the particularly active and polarized cells that are motor neurons. Paradoxically, although the particularly high-energy demand of motor neurons could make them more prone to energetic stress, endurance exercise appears to mediate the strengthening of the neuromuscular synapse. Moreover, tight regulation of mitochondrial biogenesis is of utmost importance for meeting elevated energy demands in neurons, and thus mitochondrial plasticity may adapt pre-synaptic motor neuron metabolic properties to increased energetic stress. While mitochondrial biogenesis and function have been extensively studied in muscle, much less is known regarding mitochondrial network remodeling at the neuromuscular junction upon exercise. In this study, exercise- induced changes at the neuromuscular junction were directly observed and measured using mice expressing genetically tagged mitochondria specifically in motor neurons, followed by 3D-reconstruction of synaptic structures. In addition, RNA sequencing of muscle as well as dorsal and ventral spinal cord samples from both control and long-term voluntary trained mice, enabled the identification of genes which expression was regulated upon physical activity. Thus, the present study provides insights on the regulations in gene expression that may modulate mitochondrial biogenesis and stress pathways upon physical exercise and how these changes may impact motor neuron function and ultimately mediate exercise beneficial effects. de
dc.contributor.coReferee Stegmüller, Judith Dr.
dc.subject.eng motor neuron de
dc.subject.eng mitochondria de
dc.subject.eng plasticity de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C1B-9-9
dc.affiliation.institute Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) de
dc.subject.gokfull Biologie (PPN619462639) de
dc.identifier.ppn 869904418

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