• Understanding Nucleosome Assembly Regulation in Drosophila melanogaster 

  Mühlen, Dominik (2022-06-24)

  Nucleosomes consist of a complex of DNA and an octameric core of histone proteins, which represent the basic subunit of chromatin. The N-terminal tails of histones are target for chemical modifications, which play an ...

• From annotation to bacterial data models 

  Pedreira, Tiago (2022-06-24)

  Science and technological advancements walk side-by-side and with the recent emergence of novel high throughput techniques, the necessity to have specialized data structures to host and represent the complex and high variety ...

• Regulation of vesicular trafficking in presence of mutations in contractile proteins 

  Dai, Yuanyuan (2022-06-20)

  The molecular and cellular mechanisms underlying disease phenotypes in dilated cardiomyopathy (DCM) are diverse and to date incompletely understood. Inherited mutations in genes encoding structural components of the sarcomere ...

• Characterization of immune responses in the meninges 

  Merlini, Arianna (2022-06-14)

  Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which is characterized by plaque-like demyelination in both white and grey matter and diffuse neurodegeneration. A T cell-driven ...

• Molecular Control of Germ Plasm Localization in Zebrafish 

  Rostam, Nadia (2022-05-24)

  Germ plasm (GP) consists of a maternally inherited ribonucleo-protein (RNP) condensate, which controls in many animals the formation of germline. Only the cells which contain GP commit to germ cell destinies, whereas all ...

• Development of methods to decrease aneuploidy in mammalian oocytes 

  Altmeppen, Gerrit (2022-05-24)

  Maternal mRNAs accompany and control all processes from the onset of meiosis until the blastocyst stage when the maternal pool of mRNAs is fully replaced by the emryonic mRNA set. The successful development of blastocysts ...

• The role of proteasome generated spliced peptides in the adaptive immune response 

  Mansurkhodzhaev, Artem (2022-05-20)

  CD8+ T-cells are the crucial component of the adaptive immune system as they survey the cells of the body for the signs of pathogens or tumours and eliminate them when necessary. To do this, T-cells recognise short antigenic ...

• Protein Interactions in minimal cells 

  Singh, Neil (2022-05-18)

  Minimal cells are used to model and understand life’s complex processes. The most essential processes of life are thought to include cell replication, energy metabolism and genome maintenance. However, construction of a ...

• The role of GTPases in human mitochondrial ribosome biogenesis 

  Lavdovskaia, Elena (2022-05-03)

  Mitochondria are essential organelles of eukaryotic cells, which produce the vast majority of the cellular ATP via oxidative phosphorylation (OXPHOS). The mitochondrial gene expression machinery contributes to the formation ...

• Decoding and influencing mitochondrial inner membrane ultra-structure biogenesis 

  Mukherjee, Indrani (2022-04-28)

  The Mitochondrion is a ubiquitous organelle known to be involved in a variety of vital cellular functions besides its central role in ATP synthesis such as, cellular metabolism, signalling and apoptosis. Dynamic in both ...

• Strategies for dynamic vision in the Drosophila peripheral visual system 

  Ketkar, Madhura D. (2022-04-21)

  Changes in luminance over space and time drive visual behaviors across species. Thus, sensitivity to luminance changes or contrast is fundamental to visual perception. Visual perception has to work in many different ...

• Chromatin reorganization, signaling responses and non-coding RNA regulators in homeostasis and senescence 

  Josipovic, Natasa (2022-04-21)

  In mammalian cells, a relatively limited fraction of genetic information is utilized in a variety of ways to give rise to distinct cellular phenotypes. Thus, the genotype essentially acts as input for multilayered regulatory ...

• Analysis of multiprotein-complex components pulled-down with STRIPAK in Sordaria macrospora 

  Groth, Anika (2022-04-14)

  The striatin-interacting phosphatase and kinase (STRIPAK)-complex is highly conserved and can be found in fungi and animals. In the filamentous ascomycete Sordaria macrospora (Sm), the SmSTRIPAK plays an important role in ...

• Identification of a novel subnetwork involved in eye size variation between Drosophila melanogaster and D. mauritiana 

  Lu, Ting-Hsuan (2022-04-07)

  The Mendelian genetics concept relies on simple genotype-phenotype relationships with few genes having major effects on the phenotype. However, many traits evolve by a combination of variation in many genomic loci with ...

• Imaging Network Alterations in Patients With Genetic Generalized Epilepsy and Their Healthy Siblings Using Magneto- and Electroencephalography 

  Stier, Christina (2022-04-05)

  Genetic generalized epilepsy (GGE) is a common epilepsy syndrome and represents the largest group of epilepsies suspected to have a complex genetic etiology. Specific time windows for age of onset and various seizure types ...

• Exploring the human Hsp70-Hop-Hsp90 system for Tau recognition 

  Moll, Antonia (2022-03-22)

  Molecular chaperones are diligent helpers of the cell that ensure a well-balanced proteome by regulating protein production, protein folding, refolding and holding as well as protein degradation. In doing so, molecular ...

• From Paramagnetic Proteins to Field Alignment of Small Molecules 

  Karschin, Niels Ulrich (2022-03-17)

  In this dissertation we show how to push the boundaries of structure elucidation using tensorial NMR parameters. Possible sources for these effects are paramagnetic centers or molecular alignment, and they contain valuable ...

• Purification of organellar macromolecular complexes for structural biology 

  Dakshinamoorthy, UmaLakshmi (2022-03-14)

  Photosynthesis is the source of life on Earth. In oxygenic photosynthesis, water and carbon dioxide are converted into organic matter using of solar energy that results in the release of oxygen. PSII, a supra-molecular ...

• Bioinformatics analysis of multi-omics data elucidates the primary function of Oct4 in gene regulation and pluripotency maintenance 

  Xiong, Le (2022-03-14)

  The transcription factor (TF) Oct4 is essential for maintaining pluripotency in vitro as well as in vivo. The crucial function of Oct4 in control of pluripotency has been extensively studied during reprogramming of somatic ...

• Network formation and reorganization of the olfactory system of Xenopus laevis 

  Hawkins, Sara Joy (2022-03-03)

  The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ...

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