Zentren & Graduiertenschulen
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CBL - Zentrum für Biodiversität und Nachhaltige Landnutzung (ehem. GZBÖ) [100]
CBL - Centre of Biodiversity and sustainable Land Use -
GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1107]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences -
GZMB - Göttinger Zentrum für molekulare Biowissenschaften [38]
GCMB - Göttingen Center for Molecular Biosciences
Neueste Zugänge
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The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
Vegetation dynamics of the East- European forest-steppe since the Late Glacial: climate, human and fire impact
(2024-03-11)While many studies have documented changes of the northern latitudinal forest limit in Europe and its drivers, little is known about the southern latitudinal limit of the forest towards the steppe in Eastern Europe. ... -
Investigating the Ultrastructural Consequences of Aging on Murine Inner Hair Cell Ribbon Synapses
(2024-03-05)The ribbon synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are first synapses of the auditory pathway. They mediate the harmonized and tireless neurotransmission needed for continuous sound ... -
Amino acid metabolism in Bacillus subtilis
(2024-03-05)Amino acid metabolism is a a central field of research aiming to understand the complex reactions that take place in a cell. Amino acids are the main building blocks for proteins, and they serve as carbon or nitrogen source ... -
Mechanisms underlying age-related decline in mammalian female fertility
(2024-03-05)Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited ... -
Structural and functional studies of RNA polymerase II passage through nucleosomes
(2024-03-05)Transcription by RNA polymerase II (Pol II) is an essential process of life occurring in the context of the compact eukaryotic nucleus. While transcription elongation has been extensively studied on linear DNA in vitro, ... -
Molecular characterization of protein translocation pores
(2024-02-27)Within the intricate realm of intracellular protein transport, individual organelles are reliant upon precise and dedicated protein machineries, commonly referred to as translocon, to facilitate the translocation of proteins ... -
Identification and characterization of plant lipid droplet-associated proteins
(2024-02-23)The molecular study of plant lipid droplets, first described over a century ago, has garnered attention since the identification of oleosins in the 1980s’. In recent years, considerable progress has been achieved in ... -
Multi-nuclear magnetic resonance imaging and spectroscopy of lithium in the brain
(2024-02-23)Equipped with only three protons, lithium stands as one of the most unexpected drug discoveries in history. Despite its initial FDA approval in 1970, lithium's precise mechanism for regulating mood remains largely elusive. ... -
Assessing sociality: catarrhine microsatellites and the dynamics of glucocorticoids with social relationships in wild male Assamese macaques (Macaca assamensis)
(2024-02-22)In order to navigate within-group competition and maximise fitness, strategies have evolved in group-living animals, including social dominance ranks and affiliative relationships. Both of these play a crucial role in ... -
Functional connectivity of the L2/3 VIP-to-L4 SST cell circuit motif in the primary somatosensory and visual cortices of mouse
(2024-02-19)The mammalian cortex is comprised of a multitude of cell types, wired together in intricate circuit motifs, which are recruited during different behavioral scenarios. Broadly speaking, neocortical neurons can either be ... -
Multi-omics studies of transcription regulatory mechanisms during human cell fate transition
(2024-02-16)RNA polymerase II (Pol II) transcription is an essential process in living organisms that requires accurate regulation and coordination in order to produce protein-coding and many types of non-coding transcripts. One of ... -
The Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel in Sharp Wave Ripples, Place Cells, and Spatial Memory
(2024-02-09)Previous research in our lab found impaired long-term potentiation (LTP) of CA3-CA1 synapses, a fundamental process for learning and memory, in transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice. The TRPV1 ... -
Bayesian Structural Ensemble Determination from Single-Molecule X-ray Scattering
(2024-02-09)Single-molecule X-ray scattering experiments using ultrashort X-ray free electron laser (XFEL) pulses have opened a new route for the structure determination of biomolecules. They also hold the potential to extract the ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Functional characterization of protease inhibitors involved in induced systemic defenses in poplar
(2024-02-05)Plants are constantly challenged with biotic stresses. Stresses are gaining importance due to climate change, where extended periods of warmer conditions are expected globally. Extended warmer temperatures also mean longer ... -
Mechanisms underlying postoperative pain – A translational study
(2024-02-05)The current focus on pain following surgery is in understanding the mechanisms behind it to develop methods to reduce its impact in patients. Surgery is necessary for treating several diseases and conditions; therefore, ... -
Mechanistic Investigation of the Mode of Action of the Antimicrobial Peptide Lugdunin in Lipid Membranes
(2024-01-26)Dissemination of infections originating from antibiotic-resistant bacteria constitutes an escalating threat to global healthcare systems further compounded by the stagnant development of novel antibiotics. Therefore, the ... -
Neural network integration from multimodal imaging in epilepsy and healthy controls
(2024-01-17)Different imaging modalities can be used to probe distinct aspects of the brain, such as cerebral anatomy (MRI), tissue diffusion directions (DTI), metabolic activity (PET), neurovascular activity (fMRI), or electrophysiological ... -
Comparative genome and phenotypic analysis of Clostridioides difficile strains
(2024-01-16)The anaerobic bacterium Clostridioides difficile, renamed from Clostridium difficile, substantially accounts for nosocomial, antibiotic-associated infections worldwide. The complex dynamics of various traits shape the ...