• Characterization of the Complexin - SNARE Protein Network in Different Synaptic Systems 

  Meyer, Jutta (2023-01-24)

  At neuronal synapses, the exocytotic SNARE complex is formed by Syntaxin 1, SNAP25 and Synaptobrevin 2. Complexin (Cplx) regulates the SNARE function to achieve the high speed and spatial precision of synaptic vesicle ...

• Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration 

  Skamrahl, Mark (2023-01-13)

  Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ...

• Validation of novel protein-protein interactions in Bacillus subtilis 

  Bremenkamp, Rica (2023-01-12)

  Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ...

• Metabolism of NHP and SA 

  Mohnike, Lennart (2023-01-02)

  When mobile organisms face a threat, they have the options of a fight or flight as reaction. The sessile nature of plants narrows their response option down to defend themselves against the threat. Therefore, plants developed ...

• Bat activity and diversity in a temperate old-growth forest - Influence of horizontal and vertical structural heterogeneity on the bat assemblage of the Belovezhskaya Pushcha, Belarus 

  Erasmy, Maude (2022-12-21)

  There are two different options to manage forests in the era of global climate warming, with partly opposing inferences. One is to reduce management or abandon it, as undisturbed forest ecosystems effectively store carbon ...

• Assembly pathway of the fungal COP9 signalosome 

  Bakti, Fruzsina Erzsébet (2022-12-20)

  The conserved eight-subunit COP9 signalosome (CSN complex) controls the exchange of E3 ubiquitin cullin RING ligase receptors, and therefore the specificity of protein degradation in eukaryotic cells and it is required ...

• Long-term vegetation dynamics along altitudinal and longitudinal gradients in the Hyrcanian forest region (northern Iran) 

  Homami Totmaj, Leila (2022-12-14)

  As an Arcto-Tertiary species refugium, the Hyrcanian forest region of Iran, may play an important role in investigating paleoclimatic and palaeoecological changes. This narrow belt, located between the biggest lake of the ...

• A Minimal Approach to the Dynamic Regulation of Biomolecular Conformation 

  Vossel, Maximilian (2022-12-14)

  Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and other biological macromolecules. It forms the basis for controlling various inter- and intracellular processes. Allosteric ...

• Translation Termination in Human Mitochondria: The Role of mtRF1 and mtRF1a 

  Nadler, Franziska (2022-12-09)

  Translation termination is the last step of ribosomal protein synthesis. Dedicated translation factors are imported into mitochondria to convert the information stored in the retained mitochondrial DNA (mtDNA) and to ...

• Holocene climate changes, sea-level oscillations and humans impact in northeastern Brazil 

  Alves de Moraes, Caio (2022-12-05)

  During the Holocene, the environment in northeastern Brazil has changed mainly due to climate dynamics, human activities, and in the coastal area, sea-level oscillations. However, little is known about the environmental ...

• Automated STED microscopy for cell-biological high-throughput assays 

  Bierbaum, Sebastian (2022-11-28)

  In the past decade, super-resolution fluorescence microscopy has revolutionized biological research by enabling the study of biological functions down to the molecular scale. Despite profound technological developments, ...

• Functional and Structural Characterization of the DEAH-box Helicase Prp43 

  Enders, Marieke (2022-11-24)

  RNA helicases of the DEAH-box family fulfill essential functions in various aspects of RNA metabolism by reorganizing structured RNAs and RNPs through ATP-dependent motility in 3’ to 5’ direction along single-strands. Prp43 ...

• Prenatal maternal stress effects in wild Assamese macaques (Macaca assamensis) 

  Anzà, Simone (2022-11-22)

  Across mammals, adverse conditions experienced during specific ontogenetic sensitive periods can have persisting effects on neurodevelopment, acquisition of cognitive and motoric skills, immune function, and systemic ...

• Cystic Fibrosis as a model use case for implementing cell based disease models in systems medicine 

  Vinhoven, Liza (2022-11-22)

  In the last two decades, tremendous progress has been made in producing large amounts of biological and biomedical data in a time- and cost-effective manner. Along with the increasing amount of data has come the requirement ...

• Droplet-based giant unilamellar vesicles as a tool for pore-spanning membrane preparation and transmembrane protein reconstitution 

  Kramer, Kristina (2022-11-22)

  Model membranes represent a central tool to decipher complex processes of living cells. Giant unilamellar vesicles (GUVs) are of particular interest as they are cell-like in size, observable with optical microscopy and ...

• Dynamics and self-organization of membrane-bound minimal actin and actomyosin cortices based on ezrin-PtdIns[4,5]P2 linkage 

  Liebe, Nils (2022-11-22)

  The cellular cortex is a thin actin layer attached to the cytoplasmatic plasma membrane leaflet of mammalian cells. Through a complex interaction with hundreds of actin binding proteins (ABPs), controlling e.g. the cortex ...

• Reconstructing the electrical dynamics on the heart 

  Rüchardt, Baltasar (2022-11-09)

  The heart is an electro-mechanical system. In 2010 about 4.25 million people died from cardiac arrhythmias. Immediate treatment in case of fibrillation is to shock the heart electrically with high energy to reset the ...

• Non-canonical functions of the MDM2 oncoprotein 

  Manzini, Valentina (2022-11-04)

  The tumour suppressor gene TP53 is mutated in ~50% of human cancers. The p53 protein is a transcription factor which is induced by several cellular stresses, such as ribosomal stress and DNA damage. Expression of its target ...

• Modelling the Dynamics of Actomyosin Networks 

  Kuhlemann, Ilyas (2022-11-04)

  In this dissertation, a new framework called bead-state model (BSM) for computer simulations of actin networks is presented, and its scientific validity and its usability and flexibility is demonstrated in three ...

• Co-translational processing and membrane insertion of proteins in bacteria 

  Bögeholz, Lena A. K. (2022-11-04)

  Protein biogenesis entails the synthesis of polypeptides on the ribosome, their co- and post-translational maturation, folding, and, in the case of membrane proteins, insertion into the lipid bilayer. Bacterial proteins ...

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