In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ...
Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ...
Large macromolecular protein complexes play an important role in the quest of un- derstanding life at a molecular level. For this endeavor, the highly-resolved 3D structure of a large complex and its changes, which are ...
Auditory neuropathy and auditory synaptopathy are hearing disorders with normal outer hair cell function and cochlear amplification, but an impairment in the function of inner hair cells, their ribbon synapses, or in the ...
During all steps of nuclear RNA maturation, aberrant RNAs can be generated. However, nuclear quality control mechanisms ensure that immature or aberrant RNAs are retained in the nucleus and subsequently degraded to prevent ...