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dc.contributor.advisor Hänßle, Holger PD Dr.
dc.contributor.author Samhaber, Kinga
dc.date.accessioned 2016-11-09T11:11:10Z
dc.date.available 2016-11-23T23:50:06Z
dc.date.issued 2016-11-09
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7C9B-7
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title In-vivo-konfokale Laserscanmikroskopie: Diagnostische Kriterien für die Differenzierung vesikulöser/ bullöser Dermatosen de
dc.type doctoralThesis de
dc.title.translated Morphologic criteria of vesiculobullous skin disorders by in vivo reflectance confocal microscopy de
dc.contributor.referee Hänßle, Holger PD Dr.
dc.date.examination 2016-11-16
dc.description.abstracteng Background and Objectives: Reflectance confocal microscopy (RCM) may aid an accurate, rapid, and non-invasive diagnosis of vesiculobullous skin diseases (VSD) at bedside. The main outcome measure of this study was a descriptive statistical analysis of RCM features associated with selected VSD. Patients and Methods: Single-center, observational study at a university-based dermatology department. Forty skin lesions in 24 patients with bullous pemphigoid (BP), varicella zoster infection (VZI), or allergic contact dermatitis (ACD) were assessed. Results: Patients with BP, VZI, and ACD were assessed for presence of a large panel of RCM features including, among others, histopathologic correlates for spongiosis, vesicles/bullae, epidermal necrosis, pleomorphic ballooned keratinocytes, and inflammatory infiltrate. The three conditions showed distinct patterns for the presence of RCM features. Using a multivariate regression model, we identified sets of morphologic features in BP (vesicles/bullae at the dermo-epidermal junction, inflammatory infiltrate within bullae and basal epidermal layers, spongiosis in basal epidermal layers), VZI (acantholysis in the stratum spinosum, epidermal necrosis, pleomorphic ballooned keratinocytes, multinucleated giant cells), and ACD (microvesicles, spongiosis, and prominent inflammatory infiltrate in the stratum granulosum/spinosum). Conclusions: RCM seems to be a useful tool in the evaluation and differentiation of a selected group of VSD, and offers a good correlation with histopathological findings. de
dc.contributor.coReferee Becker, Jürgen PD Dr.
dc.subject.ger konfokale Laserscanmikroskopie de
dc.subject.ger Varizella zoster de
dc.subject.ger allergische Kontaktdermatitis de
dc.subject.ger bullöses Pemphigoid de
dc.subject.eng reflectance confocal microscopy de
dc.subject.eng bullous pemphigoid de
dc.subject.eng varicella zoster infection de
dc.subject.eng allergic contact dermatitis de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C9B-7-8
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.subject.gokfull Dermatologie / Venerologie - Allgemein- und Gesamtdarstellungen (PPN619876174) de
dc.description.embargoed 2016-11-23
dc.identifier.ppn 872334767

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