In-vivo-konfokale Laserscanmikroskopie: Diagnostische Kriterien für die Differenzierung vesikulöser/ bullöser Dermatosen

Samhaber, Kinga

dc.contributor.advisor	Hänßle, Holger PD Dr.
dc.contributor.author	Samhaber, Kinga
dc.date.accessioned	2016-11-09T11:11:10Z
dc.date.available	2016-11-23T23:50:06Z
dc.date.issued	2016-11-09
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002B-7C9B-7
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5937
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	In-vivo-konfokale Laserscanmikroskopie: Diagnostische Kriterien für die Differenzierung vesikulöser/ bullöser Dermatosen	de
dc.type	doctoralThesis	de
dc.title.translated	Morphologic criteria of vesiculobullous skin disorders by in vivo reflectance confocal microscopy	de
dc.contributor.referee	Hänßle, Holger PD Dr.
dc.date.examination	2016-11-16
dc.description.abstracteng	Background and Objectives: Reflectance confocal microscopy (RCM) may aid an accurate, rapid, and non-invasive diagnosis of vesiculobullous skin diseases (VSD) at bedside. The main outcome measure of this study was a descriptive statistical analysis of RCM features associated with selected VSD. Patients and Methods: Single-center, observational study at a university-based dermatology department. Forty skin lesions in 24 patients with bullous pemphigoid (BP), varicella zoster infection (VZI), or allergic contact dermatitis (ACD) were assessed. Results: Patients with BP, VZI, and ACD were assessed for presence of a large panel of RCM features including, among others, histopathologic correlates for spongiosis, vesicles/bullae, epidermal necrosis, pleomorphic ballooned keratinocytes, and inflammatory infiltrate. The three conditions showed distinct patterns for the presence of RCM features. Using a multivariate regression model, we identified sets of morphologic features in BP (vesicles/bullae at the dermo-epidermal junction, inflammatory infiltrate within bullae and basal epidermal layers, spongiosis in basal epidermal layers), VZI (acantholysis in the stratum spinosum, epidermal necrosis, pleomorphic ballooned keratinocytes, multinucleated giant cells), and ACD (microvesicles, spongiosis, and prominent inflammatory infiltrate in the stratum granulosum/spinosum). Conclusions: RCM seems to be a useful tool in the evaluation and differentiation of a selected group of VSD, and offers a good correlation with histopathological findings.	de
dc.contributor.coReferee	Becker, Jürgen PD Dr.
dc.subject.ger	konfokale Laserscanmikroskopie	de
dc.subject.ger	Varizella zoster	de
dc.subject.ger	allergische Kontaktdermatitis	de
dc.subject.ger	bullöses Pemphigoid	de
dc.subject.eng	reflectance confocal microscopy	de
dc.subject.eng	bullous pemphigoid	de
dc.subject.eng	varicella zoster infection	de
dc.subject.eng	allergic contact dermatitis	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C9B-7-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Dermatologie / Venerologie - Allgemein- und Gesamtdarstellungen (PPN619876174)	de
dc.description.embargoed	2016-11-23
dc.identifier.ppn	872334767

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Human- und Zahnmedizin [2873]

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