Navigation ▼

Show simple item record

dc.contributor.advisor Kube, Dieter Prof. Dr.
dc.contributor.author Ueberdiek, Stefan
dc.date.accessioned 2016-11-18T07:51:02Z
dc.date.available 2016-11-19T23:50:15Z
dc.date.issued 2016-11-18
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7CB1-4
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Einfluss von LEF1 auf das Tumorwachstum im Burkitt-Lymphom-Xenograft-Modell de
dc.type doctoralThesis de
dc.title.translated Influence of LEF1 on tumor growth in a Burkitt-Lymphoma-Xenograft-Model de
dc.contributor.referee Kube, Dieter Prof. Dr.
dc.date.examination 2016-10-27
dc.description.abstracteng Because of the limited knowledge about the biology of the highly aggressive Burkitt- Lymphoma is still possible in many cases no cure, it is all the more important, Possible therapeutic approaches. One possible starting point is the Transcription factor LEF-1, which is aberrantly expressed in BL cells. But for that Still have many more insights about the function of LEF1 in Burkitt's lymphoma be won. In this work the further establishment and characterization of the LEF1-KD as well as the Scrb-shRNA-BL2 cell lines. Furthermore, the Xenograft model CAM assay as a suitable model for the study of LEF1-aberrant and LEF1-deficient Burkitt's lymphoma. With regard to the biological function of LEF1 in the BL2 cells, ovo Significantly smaller tumor areas of LEF1-deficient Burkitt's lymphomas compared to The LEF1-aberrant Burkitt's lymphomas. From this finding, the underlying tumor characteristics such as Growth of tumors and cell proliferation, That LEF1 has positively regulating influences on these aspects. More information Were found to have positive effects on LEF1 and migration Invasiveness of lymphoma cells. Because the tumor microenvironment, which is characterized by the MatriGel was able to improve significantly from LEF1-aberrant lymphoma cells Can be decomposed. de
dc.contributor.coReferee Wilting, Jörg Prof. Dr.
dc.subject.eng LEF1 de
dc.subject.eng Burkitt-Lymphoma de
dc.subject.eng CAM-Assay de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7CB1-4-7
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.description.embargoed 2016-11-19
dc.identifier.ppn 872808165 872808149

Files in this item

This item appears in the following Collection(s)

Show simple item record