| dc.contributor.advisor | Kube, Dieter Prof. Dr. | |
| dc.contributor.author | Ueberdiek, Stefan | |
| dc.date.accessioned | 2016-11-18T07:51:02Z | |
| dc.date.available | 2016-11-19T23:50:15Z | |
| dc.date.issued | 2016-11-18 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002B-7CB1-4 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5958 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Einfluss von LEF1 auf das Tumorwachstum im Burkitt-Lymphom-Xenograft-Modell | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Influence of LEF1 on tumor growth in a Burkitt-Lymphoma-Xenograft-Model | de |
| dc.contributor.referee | Kube, Dieter Prof. Dr. | |
| dc.date.examination | 2016-10-27 | |
| dc.description.abstracteng | Because of the limited knowledge about the biology of the highly aggressive Burkitt-
Lymphoma is still possible in many cases no cure, it is all the more important,
Possible therapeutic approaches. One possible starting point is the
Transcription factor LEF-1, which is aberrantly expressed in BL cells. But for that
Still have many more insights about the function of LEF1 in Burkitt's lymphoma
be won.
In this work the further establishment and characterization of the LEF1-KD as well as the
Scrb-shRNA-BL2 cell lines. Furthermore, the Xenograft model
CAM assay as a suitable model for the study of LEF1-aberrant and LEF1-deficient
Burkitt's lymphoma.
With regard to the biological function of LEF1 in the BL2 cells, ovo
Significantly smaller tumor areas of LEF1-deficient Burkitt's lymphomas compared to
The LEF1-aberrant Burkitt's lymphomas.
From this finding, the underlying tumor characteristics such as
Growth of tumors and cell proliferation,
That LEF1 has positively regulating influences on these aspects. More information
Were found to have positive effects on LEF1 and migration
Invasiveness of lymphoma cells. Because the tumor microenvironment, which is characterized by the
MatriGel was able to improve significantly from LEF1-aberrant lymphoma cells
Can be decomposed. | de |
| dc.contributor.coReferee | Wilting, Jörg Prof. Dr. | |
| dc.subject.eng | LEF1 | de |
| dc.subject.eng | Burkitt-Lymphoma | de |
| dc.subject.eng | CAM-Assay | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7CB1-4-7 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2016-11-19 | |
| dc.identifier.ppn | 872808165
872808149 | |